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Am J Physiol Regul Integr Comp Physiol 278: R331-R336, 2000;
0363-6119/00 $5.00
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Vol. 278, Issue 2, R331-R336, February 2000

Effects of vagotomy on serum endotoxin, cytokines, and corticosterone after intraperitoneal lipopolysaccharide

Michael K. Hansen1, Kien T. Nguyen1, Monika Fleshner2, Lisa E. Goehler1, Ron P. A. Gaykema1, Steven F. Maier1, and Linda R. Watkins1

1 Department of Psychology and 2 Department of Kinesiology and Applied Physiology, University of Colorado, Boulder, Colorado 80309

The vagus nerve appears to play a role in communicating cytokine signals to the central nervous system, but the exact extent of its involvement in cytokine-to-brain communication remains controversial. Recently, subdiaphragmatic vagotomy was shown to increase bacterial translocation across the gut barrier and thus may cause endotoxin tolerance. The current experiment tested whether or not vagotomized animals have similar systemic responses to endotoxin challenge as do sham-operated animals. Subdiaphragmatically vagotomized and sham-operated animals were injected intraperitoneally with one of three doses (10, 50, 100 µg/kg) of lipopolysaccharide (LPS) or vehicle, and blood samples were taken at 15, 30, 60, 90, and 120 min after the injection. The intraperitoneal injection of LPS increased circulating LPS levels at all time points examined. In addition, all three doses of LPS significantly increased serum interleukin (IL)-1beta , IL-6, and corticosterone in both control and vagotomized rats. In conclusion, vagotomy itself has no marked effect on circulating endotoxin levels or the production of IL-1beta , IL-6, or corticosterone in blood after an intraperitoneal injection of LPS.

interleukin-1beta ; interleukin-6; vagus nerve; cytokine-to-brain communication


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