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Am J Physiol Regul Integr Comp Physiol 278: R345-R351, 2000;
0363-6119/00 $5.00
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Vol. 278, Issue 2, R345-R351, February 2000

Reduction of food intake by intestinal macronutrient infusion is not reversed by NMDA receptor blockade

M. Covasa, R. C. Ritter, and G. A. Burns

College of Veterinary Medicine, Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, Washington 99164

Rats increase their intake of food, but not water, after intraperitoneal injection of MK-801, a noncompetitive antagonist of N-methyl-D-aspartate-activated ion channels. We hypothesized that MK-801 might enhance intake by interfering with intestinal chemosensory signals. To test this hypothesis, we examined the effect of the antagonist on 15% sucrose intake after an intraduodenal infusion of maltotriose, oleic acid, or phenylalanine in both real- and sham-feeding paradigms. MK-801 (100 µg/kg) significantly increased sucrose intake regardless of the composition of the infusate during real feeding. Furthermore, MK-801 had no effect on reduction of sucrose intake by intestinal nutrient infusions in sham-feeding rats. These results indicate that MK-801 does not increase meal size and duration by interfering with signals activated by intestinal macronutrients.

sham feeding; intestinal infusion; satiety


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