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Am J Physiol Regul Integr Comp Physiol 278: R494-R498, 2000;
0363-6119/00 $5.00
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Vol. 278, Issue 2, R494-R498, February 2000

Effect of NPY in the hypothalamic paraventricular nucleus on uncoupling proteins 1, 2, and 3 in the rat

C. M. Kotz1,2, C. F. Wang1, J. E. Briggs3, A. S. Levine1,2,4, and C. J. Billington1,3

1 Minnesota Obesity Center, Veterans Affairs Medical Center, Minneapolis 55417; and Departments of 2 Food Science and Nutrition, 3 Medicine, and 4 Psychiatry, University of Minnesota, Saint Paul, Minnesota 55108

Neuropeptide Y (NPY) injected into the hypothalamic paraventricular nucleus (PVN) stimulates feeding and decreases uncoupling protein (UCP)-1 mRNA in brown adipose tissue (BAT). The present studies were undertaken to determine whether UCP-2 in white adipose tissue (WAT) and UCP-3 in muscle are regulated by NPY in the PVN. PVN-cannulated male Sprague-Dawley rats were injected with either saline or NPY (PVN, 117 pmol, 0.5 µl) every 6 h for 24 h. NPY in the PVN stimulated feeding and decreased UCP-1 mRNA in BAT independent of NPY-induced feeding. UCP-2 mRNA in WAT was unchanged by NPY. In acromiotrapezius muscle, NPY decreased UCP-3 mRNA, but this was reversed by restricting food intake to control levels. In biceps femoris muscle, NPY alone had no effect on UCP-3 mRNA, but UCP-3 mRNA was significantly increased in the NPY-treated rats that were restricted to control levels of intake. These results suggest that UCP-2 in WAT and UCP-3 in muscle are not subject to specific regulation by NPY in the PVN.

thermogenesis; brown adipose tissue; white adipose tissue; muscle


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