AJP - Regu Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 278: R537-R543, 2000;
0363-6119/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (24)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Finck, B. N.
Right arrow Articles by Johnson, R. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Finck, B. N.
Right arrow Articles by Johnson, R. W.
Vol. 278, Issue 2, R537-R543, February 2000

Tumor necrosis factor (TNF)-alpha induces leptin production through the p55 TNF receptor

Brian N. Finck and Rodney W. Johnson

Laboratory of Integrative Biology, Department of Animal Sciences, University of Illinois, Urbana, Illinois 61801

Tumor necrosis factor (TNF)-alpha acts directly on adipocytes to increase production of the lipostatic factor, leptin. However, which TNF receptor (TNFR) mediates this response is not known. To answer this question, leptin was measured in plasma of wild-type (WT), p55, and p75 TNFR knockout (KO) mice injected intraperitoneally with murine TNF-alpha and in supernatants from cultured WT, p55, and p75 TNFR KO adipocytes incubated with TNF-alpha . Leptin also was measured in supernatants from C3H/HeOuJ mouse adipocytes cultured with blocking antibodies to each TNFR and TNF-alpha as well as in supernatants from adipocytes incubated with either human or murine TNF-alpha , which activate either one or both TNFR, respectively. The results using all four strategies show that the induction of leptin production by TNF-alpha requires activation of the p55 TNFR and that although activation of the p75 TNFR alone cannot cause leptin production, its presence affects the capability of TNF-alpha to induce leptin production through the p55 TNFR. These results provide new information on the interplay between cells of the immune system and adipocytes.

tumor necrosis factor receptor; ob gene; cytokine; adipocytes


This article has been cited by other articles:


Home page
 Reproductive SciencesHome page
S. Lambin, R. van Bree,, I. Vergote, and J. Verhaeghe
Chronic Tumor Necrosis Factor-{alpha} Infusion in Gravid C57BL6/J Mice Accelerates Adipose Tissue Development in Female Offspring
Reproductive Sciences, December 1, 2006; 13(8): 558 - 565.
[Abstract] [PDF]

Home page
 Ann Rheum DisHome page
P Harle, G Pongratz, C Weidler, R Buttner, J Scholmerich, and R H Straub
Possible role of leptin in hypoandrogenicity in patients with systemic lupus erythematosus and rheumatoid arthritis
Ann Rheum Dis, July 1, 2004; 63(7): 809 - 816.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
C Zamarron, F Maceiras, A Mera, and J J Gomez-Reino
Effect of the first infliximab infusion on sleep and alertness in patients with active rheumatoid arthritis
Ann Rheum Dis, January 1, 2004; 63(1): 88 - 90.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
B. N. Finck and R. W. Johnson
Anti-inflammatory agents inhibit the induction of leptin by tumor necrosis factor-alpha
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2002; 282(5): R1429 - R1435.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
L. Gambling, Z. Charania, L. Hannah, C. Antipatis, R. G. Lea, and H. J. McArdle
Effect of Iron Deficiency on Placental Cytokine Expression and Fetal Growth in the Pregnant Rat
Biol Reprod, February 1, 2002; 66(2): 516 - 523.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
G. Fruhbeck, J. Gomez-Ambrosi, F. J. Muruzabal, and M. A. Burrell
The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation
Am J Physiol Endocrinol Metab, June 1, 2001; 280(6): E827 - E847.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online