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Department of Physiology and Biophysics, University of Nebraska Medical Center, Omaha, Nebraska 68198-4545
Experiments were performed to determine if there is
regional heterogeneity in sympathetic neural activation of peripheral tissues in rats with chronic heart failure (HF; 6-8 wk after
coronary artery ligation). Norepinephrine (NE) turnover, an index of
sympathetic activation, was determined on the basis of the decline in
tissue NE levels that occurs during the 8-h after tyrosine hydroxylase inhibition (
-methyl-DL-p-tyrosine, 300 mg/kg ip at 4-h
intervals). Compared with sham-operated rats, NE turnover was increased
in the cardiac left ventricle, skeletal muscle, duodenum, and kidney of
rats with HF, but was unaltered in liver and spleen. The increased renal NE turnover in HF was largely a reflection of increased turnover
in the cortex, with no change evident in the medulla. Blockade of
sympathetic ganglionic traffic (hexamethonium, 2 mg/kg sc at 2-h
intervals) eliminated the tissue-specific effects of HF on tissue NE
levels measured 8-h after tyrosine hydroxylase inhibition. These data
support the contention that chronic HF evokes a central nervous
system-mediated increase in basal sympathetic tone that exhibits
regional heterogeneity (both between and within organs), a phenomenon
that likely contributes to the functional consequences of this
pathophysiological state.
myocardial infarction; sympathetic activation; renal nerve activity
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