AJP - Regu AJP: Regulatory, Integrative and Comparative Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 278: R598-R603, 2000;
0363-6119/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (14)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Johansson, C.
Right arrow Articles by Westerblad, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Johansson, C.
Right arrow Articles by Westerblad, H.
Vol. 278, Issue 3, R598-R603, March 2000

Isometric force and endurance in soleus muscle of thyroid hormone receptor-alpha 1- or -beta -deficient mice

Catarina Johansson1, Jan Lännergren1, Per-Kristian Lunde2, Björn Vennström3, Peter Thorén1, and Håkan Westerblad1

Departments of 1 Physiology and Pharmacology and 3 Cellular and Molecular Biology, Karolinska Institute, S-171 77 Stockholm, Sweden; and 2 Institute for Experimental Medical Research, Ullevaal Hospital, Oslo, Norway

The specific role of each subtype of thyroid hormone receptor (TR) on skeletal muscle function is unclear. We have therefore studied kinetics of isometric twitches and tetani as well as fatigue resistance in isolated soleus muscles of R-alpha 1- or -beta -deficient mice. The results show 20-40% longer contraction and relaxation times of twitches and tetani in soleus muscles from TR-alpha 1-deficient mice compared with their wild-type controls. TR-beta -deficient mice, which have high thyroid hormone levels, were less fatigue resistant than their wild-type controls, but contraction and relaxation times were not different. Western blot analyses showed a reduced concentration of the fast-type sarcoplasmic reticulum Ca2+-ATPase (SERCa1) in TR-alpha 1-deficient mice, but no changes were observed in TR-beta -deficient mice compared with their respective controls. We conclude that in skeletal muscle, both TR-alpha 1 and TR-beta are required to get a normal thyroid hormone response.

skeletal muscle; tetanic force; contraction; relaxation; fatigue


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
K. Wallis, M. Sjogren, M. van Hogerlinden, G. Silberberg, A. Fisahn, K. Nordstrom, L. Larsson, H. Westerblad, G. Morreale de Escobar, O. Shupliakov, et al.
Locomotor Deficiencies and Aberrant Development of Subtype-Specific GABAergic Interneurons Caused by an Unliganded Thyroid Hormone Receptor {alpha}1
J. Neurosci., February 20, 2008; 28(8): 1904 - 1915.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
C. Venero, A. Guadano-Ferraz, A. I. Herrero, K. Nordstrom, J. Manzano, G. M. de Escobar, J. Bernal, and B. Vennstrom
Anxiety, memory impairment, and locomotor dysfunction caused by a mutant thyroid hormone receptor {alpha}1 can be ameliorated by T3 treatment
Genes & Dev., September 15, 2005; 19(18): 2152 - 2163.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
R. E. Weiss, C. Korcarz, O. Chassande, K. Cua, P. M. Sadow, E. Koo, J. Samarut, and R. Lang
Thyroid hormone and cardiac function in mice deficient in thyroid hormone receptor-alpha or -beta : an echocardiograph study
Am J Physiol Endocrinol Metab, September 1, 2002; 283(3): E428 - E435.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. Schnermann
Exercise
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2002; 283(1): R2 - R6.
[Full Text] [PDF]

Home page
 FASEB J.Home page
P. WHITE, K. A. BURTON, A. L. FOWDEN, and M. J. DAUNCEY
Developmental expression analysis of thyroid hormone receptor isoforms reveals new insights into their essential functions in cardiac and skeletal muscles
FASEB J, June 1, 2001; 15(8): 1367 - 1376.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
P. K. Lunde, A. J. Dahlstedt, J. D. Bruton, J. Lannergren, P. Thoren, O. M. Sejersted, and H. Westerblad
Contraction and Intracellular Ca2+ Handling in Isolated Skeletal Muscle of Rats With Congestive Heart Failure
Circ. Res., June 22, 2001; 88(12): 1299 - 1305.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online