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Am J Physiol Regul Integr Comp Physiol 278: R604-R610, 2000;
0363-6119/00 $5.00
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Vol. 278, Issue 3, R604-R610, March 2000

Suppression of food intake, body weight, and body fat by jejunal fatty acid infusions

James E. Cox1, William J. Tyler1, Alan Randich1, Gary R. Kelm2, Satinder S. Bharaj2, Ronald J. Jandacek2, and Stephen T. Meller2

1 Department of Psychology, University of Alabama at Birmingham, Alabama 35294; and 2 Procter and Gamble, Over-the-Counter Health Care Technology Division, Health Care Research Center, Mason, Ohio 45040

Three experiments investigated effects of jejunal lipid infusions given on 4 or 21 consecutive days in adult, male Sprague-Dawley rats. In experiment 1, 7-h infusions of linoleic or oleic acid (0.2 ml/h for 7 h; total load = 11.5 kcal) on 4 consecutive days reduced total intake (ad libitum consumption of the liquid diet Boost, Mead Johnson, plus load) by ~15% and decreased weight gain compared with 4-day tests with saline administration. In experiment 2, linoleic acid at 0.1 ml/h for 7 h (5.7 kcal) was ineffective, whereas the same load delivered in 3.5 h produced effects similar in magnitude to those in the first experiment. In experiment 3, jejunal infusions of linoleic acid (0.2 ml/h for 7 h) on 21 consecutive days reduced mean total intake by 16%, body weight by 10%, and carcass fat by 48% compared with controls receiving saline. The net decrease in caloric intake may reflect the combined activation of pre- and postabsorptive mechanisms, and it suggests a possible treatment for obesity.

linoleic acid; oleic acid; satiety; small intestine


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