AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 278: R1027-R1039, 2000;
0363-6119/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (34)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Vizzard, M. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vizzard, M. A.
Vol. 278, Issue 4, R1027-R1039, April 2000

Alterations in spinal cord Fos protein expression induced by bladder stimulation following cystitis

Margaret A. Vizzard

University of Vermont College of Medicine, Departments of Neurology and Anatomy and Neurobiology, Burlington, Vermont 05405

These studies examined Fos protein expression in spinal cord neurons synaptically activated by stimulation of bladder afferent pathways after cyclophosphamide (CYP)-induced bladder inflammation. In urethan-anesthetized Wistar rats with cystitis, intravesical saline distension significantly (P <=  0.0005) increased the number of Fos-immunoreactive (IR) cells observed in the rostral lumbar (L1, 35 cells/section; L2, 27 cells/section) and caudal lumbosacral (L6, 120 cells/section; S1, 96 cells/section) spinal cord compared with control animals, but Fos protein expression in the L5 segment was not altered. The topographical distribution of Fos-IR cells was also altered in the lumbosacral spinal cord. The majority of Fos-IR cells were distributed in the dorsal commissure (45%), with smaller percentages in the sacral parasympathetic nucleus (25%), medial dorsal horn (20%), and lateral dorsal horn (10%). These results demonstrate that urinary bladder distension produces increased numbers and an altered distribution pattern of Fos-IR cells after cystitis. This altered distribution pattern resembles that following noxious irritation of the bladder in control animals. Pretreatment with capsaicin significantly reduced the number of Fos-IR cells induced by bladder distension after cystitis. These data suggest that chronic cystitis can reveal a nociceptive Fos expression pattern in the spinal cord in response to a non-noxious bladder stimulus that is partially mediated by capasaicin-sensitive bladder afferents.

interstitial cystitis; allodynia; sacral parasympathetic nucleus; spinal cord; capsaicin; choline acetyltransferase


This article has been cited by other articles:


Home page
 Am. J. Physiol. Renal Physiol.Home page
B. P. Cheppudira, B. M. Girard, S. E. Malley, K. C. Schutz, V. May, and M. A. Vizzard
Upregulation of vascular endothelial growth factor isoform VEGF-164 and receptors (VEGFR-2, Npn-1, and Npn-2) in rats with cyclophosphamide-induced cystitis
Am J Physiol Renal Physiol, September 1, 2008; 295(3): F826 - F836.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
D. Daly, W. Rong, R. Chess-Williams, C. Chapple, and D. Grundy
Bladder afferent sensitivity in wild-type and TRPV1 knockout mice
J. Physiol., September 1, 2007; 583(2): 663 - 674.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
K. A. Corrow and M. A. Vizzard
Phosphorylation of extracellular signal-regulated kinases in urinary bladder in rats with cyclophosphamide-induced cystitis
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2007; 293(1): R125 - R134.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
K. Bielefeldt, K. Lamb, and G. F. Gebhart
Convergence of sensory pathways in the development of somatic and visceral hypersensitivity
Am J Physiol Gastrointest Liver Physiol, October 1, 2006; 291(4): G658 - G665.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. LaBerge, S. E. Malley, K. Zvarova, and M. A. Vizzard
Expression of corticotropin-releasing factor and CRF receptors in micturition pathways after cyclophosphamide-induced cystitis
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2006; 291(3): R692 - R703.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
B. Chopra, S. R Barrick, S. Meyers, J. M Beckel, M. L Zeidel, A. P. D. W Ford, W. C de Groat, and L. A Birder
Expression and function of bradykinin B1 and B2 receptors in normal and inflamed rat urinary bladder urothelium
J. Physiol., February 1, 2005; 562(3): 859 - 871.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
P. Dinis, A. Charrua, A. Avelino, M. Yaqoob, S. Bevan, I. Nagy, and F. Cruz
Anandamide-Evoked Activation of Vanilloid Receptor 1 Contributes to the Development of Bladder Hyperreflexia and Nociceptive Transmission to Spinal Dorsal Horn Neurons in Cystitis
J. Neurosci., December 15, 2004; 24(50): 11253 - 11263.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C. Qin, B. Greenwood-Van Meerveld, and R. D. Foreman
Spinal Neuronal Responses to Urinary Bladder Stimulation in Rats With Corticosterone or Aldosterone Onto the Amygdala
J Neurophysiol, October 1, 2003; 90(4): 2180 - 2189.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
M. R. Saban, N.-B. Nguyen, T. G. Hammond, and R. Saban
Gene Expression Profiling of Mouse Bladder Inflammatory Responses to LPS, Substance P, and Antigen-Stimulation
Am. J. Pathol., June 1, 2002; 160(6): 2095 - 2110.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. A. Vizzard
Increased expression of spinal cord Fos protein induced by bladder stimulation after spinal cord injury
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2000; 279(1): R295 - R305.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
M. R. Saban, R. Saban, T. G. Hammond, M. Haak-Frendscho, H. Steinberg, M. W. Tengowski, and D. E. Bjorling
LPS-sensory peptide communication in experimental cystitis
Am J Physiol Renal Physiol, February 1, 2002; 282(2): F202 - F210.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online