AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 278: R824-R830, 2000;
0363-6119/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (20)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Josephs, M. D.
Right arrow Articles by Moldawer, L. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Josephs, M. D.
Right arrow Articles by Moldawer, L. L.
Vol. 278, Issue 4, R824-R830, April 2000

Modulation of the acute phase response by altered expression of the IL-1 type 1 receptor or IL-1ra

Michael D. Josephs1, Carmen C. Solorzano1, Michael Taylor1, Jason J. Rosenberg1, Daniel Topping1, Amer Abouhamze1, Sally L. D. Mackay1, Emmet Hirsch2, David Hirsh3, Mark Labow4, and Lyle L. Moldawer1

1 Department of Surgery, University of Florida College of Medicine, Gainesville, Florida 32610; Departments of 2 Obstetrics and Gynecology and 3 Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York, New York 10032; and 4 Department of Inflammation/Autoimmunity, Hoffmann-La Roche, Nutley, New Jersey 07110

A complete understanding of the role for endogenously produced interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-alpha ), and IL-1 receptor antagonist (IL-1ra) in the acute phase response to inflammation remains unknown. In the present studies, knockout mice lacking either a functional IL-1 type I receptor (IL-1RI-/-), a TNF type I receptor (TNFR-I-/-), or both IL-1 type I and TNF type I receptors (IL-1RI-/-/TNFR-I-/-) received a turpentine abscess. Additional mice deficient in IL-1ra protein (IL-1ra-/-) or overexpressing IL-1ra protein (IL-1ratg) were similarly treated. After a turpentine abscess, IL-1 receptor knockout mice exhibited an attenuated inflammatory response compared with wild-type or animals lacking a functional TNFR-I. Mice overexpressing IL-1ra also had an attenuated hepatic acute phase protein response, whereas IL-1ra knockout mice had a significantly greater hepatic acute phase response. We conclude that the inflammatory response to a turpentine abscess is the result of a balance between IL-1ra expression and IL-1 binding to its type I receptor. Endogenously produced IL-1ra plays a central role in mitigating the magnitude of the IL-1-mediated inflammatory response and, ultimately, the outcome to a turpentine abscess.

anorexia; cachexia; tumor necrosis factor; interleukin-6


This article has been cited by other articles:


Home page
 Am. J. Respir. Cell Mol. Bio.Home page
R. A. Johnston, J. P. Mizgerd, L. Flynt, L. J. Quinton, E. S. Williams, and S. A. Shore
Type I Interleukin-1 Receptor Is Required for Pulmonary Responses to Subacute Ozone Exposure in Mice
Am. J. Respir. Cell Mol. Biol., October 1, 2007; 37(4): 477 - 484.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
C. P. Kuo, S. W. Jao, K. M. Chen, C. S. Wong, C. C. Yeh, M. J. Sheen, and C.T. Wu
Comparison of the effects of thoracic epidural analgesia and i.v. infusion with lidocaine on cytokine response, postoperative pain and bowel function in patients undergoing colonic surgery
Br. J. Anaesth., November 1, 2006; 97(5): 640 - 646.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. S. C. Fabricio, G. Tringali, G. Pozzoli, M. C. Melo, J. A. Vercesi, G. E. P. Souza, and P. Navarra
Interleukin-1 mediates endothelin-1-induced fever and prostaglandin production in the preoptic area of rats
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2006; 290(6): R1515 - R1523.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
C. A Dinarello
Interleukin 1 and interleukin 18 as mediators of inflammation and the aging process
Am. J. Clinical Nutrition, February 1, 2006; 83(2): 447S - 455S.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
Y. Shavit, G. Fish, G. Wolf, E. Mayburd, Y. Meerson, R. Yirmiya, and B. Beilin
The Effects of Perioperative Pain Management Techniques on Food Consumption and Body Weight After Laparotomy in Rats
Anesth. Analg., October 1, 2005; 101(4): 1112 - 1116.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
C.-H. Lu, P.-C. Chao, C. O. Borel, C.-P. Yang, C.-C. Yeh, C.-S. Wong, and C.-T. Wu
Preincisional Intravenous Pentoxifylline Attenuating Perioperative Cytokine Response, Reducing Morphine Consumption, and Improving Recovery of Bowel Function in Patients Undergoing Colorectal Cancer Surgery
Anesth. Analg., November 1, 2004; 99(5): 1465 - 1471.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
C.-T. Wu, S.-W. Jao, C. O. Borel, C.-C. Yeh, C.-Y. Li, C.-H. Lu, and C.-S. Wong
The Effect of Epidural Clonidine on Perioperative Cytokine Response, Postoperative Pain, and Bowel Function in Patients Undergoing Colorectal Surgery
Anesth. Analg., August 1, 2004; 99(2): 502 - 509.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
F. Molina-Holgado, E. Pinteaux, J. D. Moore, E. Molina-Holgado, C. Guaza, R. M. Gibson, and N. J. Rothwell
Endogenous Interleukin-1 Receptor Antagonist Mediates Anti-Inflammatory and Neuroprotective Actions of Cannabinoids in Neurons and Glia
J. Neurosci., July 23, 2003; 23(16): 6470 - 6474.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
V. M. Irikura, M. Lagraoui, and D. Hirsh
The Epistatic Interrelationships of IL-1, IL-1 Receptor Antagonist, and the Type I IL-1 Receptor
J. Immunol., July 1, 2002; 169(1): 393 - 398.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
O. Touzani, H. Boutin, R. LeFeuvre, L. Parker, A. Miller, G. Luheshi, and N. Rothwell
Interleukin-1 Influences Ischemic Brain Damage in the Mouse Independently of the Interleukin-1 Type I Receptor
J. Neurosci., January 1, 2002; 22(1): 38 - 43.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. Cahlin, A. Körner, H. Axelsson, W. Wang, K. Lundholm, and E. Svanberg
Experimental Cancer Cachexia: The Role of Host-derived Cytokines Interleukin (IL)-6, IL-12, Interferon-{{gamma}}, and Tumor Necrosis Factor {{alpha}} Evaluated in Gene Knockout, Tumor-bearing Mice on C57 Bl Background and Eicosanoid-dependent Cachexia
Cancer Res., October 1, 2000; 60(19): 5488 - 5493.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. Bucher, J. Hobbhahn, K. Taeger, and A. Kurtz
Cytokine-mediated downregulation of vasopressin V1A receptors during acute endotoxemia in rats
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2002; 282(4): R979 - R984.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online