AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 278: R1210-R1216, 2000;
0363-6119/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (11)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cui, L.-N.
Right arrow Articles by Renaud, L. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cui, L.-N.
Right arrow Articles by Renaud, L. P.
Vol. 278, Issue 5, R1210-R1216, May 2000

GABAB presynaptically modulates suprachiasmatic input to hypothalamic paraventricular magnocellular neurons

Lu-Ning Cui, Elaine Coderre, and Leo P. Renaud

Laboratory of Neurosciences, Loeb Health Research Institute, Ottawa Hospital Civic Site; and University of Ottawa, Ottawa, Ontario, Canada K1Y 4E9

This study used whole cell patch clamp recordings in rat hypothalamic slice preparations to evaluate the effects of GABAB receptor activation on GABAA-mediated inhibitory postsynaptic currents (IPSCs) in paraventricular nucleus magnocellular neurons evoked by electrical stimulation in the suprachiasmatic nucleus (SCN). Baclofen induced a dose-dependent (1-10 µM) and reversible reduction in SCN-evoked IPSC amplitude (11/11 cells), blockable with 2-hydroxysaclofen (300 µM; 3/3 cells). IPSCs displayed paired-pulse depression (PPD), attenuated by both baclofen and 2-hydroxysaclofen, but neither altered resting membrane conductances or IPSC time constants of decay. Baclofen induced a significant dose-dependent (1-100 µM) reduction in frequency, but not amplitude, of spontaneous IPSCs and miniature IPSCs, reversible with 2-hydroxysaclofen pretreatment. Baclofen effects and PPD persisted in slices pretreated with pertussis toxin (PTX) and N-ethylmaleimide, implying that these GABAB receptors are coupled to PTX-insensitive G proteins. Responses were unaltered by barium (2 mM) or nimodipine, ruling out involvement of K+ channels and L-type Ca2+ channels. Thus pre- and postsynaptic GABAB and GABAA receptors participate in SCN entrainment of paraventricular neurosecretory neurons.

electrophysiology; patch clamp recordings; circadian rhythms; oxytocin; vasopressin


This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
R. A. Ingram, M. Fitzgerald, and M. L. Baccei
Developmental Changes in the Fidelity and Short-Term Plasticity of GABAergic Synapses in the Neonatal Rat Dorsal Horn
J Neurophysiol, June 1, 2008; 99(6): 3144 - 3150.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
N. Karpuk and A. Hayar
Activation of Postsynaptic GABAB Receptors Modulates the Bursting Pattern and Synaptic Activity of Olfactory Bulb Juxtaglomerular Neurons
J Neurophysiol, January 1, 2008; 99(1): 308 - 319.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. G. Moldavan, R. P. Irwin, and C. N. Allen
Presynaptic GABAB Receptors Regulate Retinohypothalamic Tract Synaptic Transmission by Inhibiting Voltage-Gated Ca2+ Channels
J Neurophysiol, June 1, 2006; 95(6): 3727 - 3741.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. V. Baimoukhametova, S. A. Hewitt, C. A. Sank, and J. S. Bains
Dopamine Modulates Use-Dependent Plasticity of Inhibitory Synapses
J. Neurosci., June 2, 2004; 24(22): 5162 - 5171.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
N. G. Bowery, B. Bettler, W. Froestl, J. P. Gallagher, F. Marshall, M. Raiteri, T. I. Bonner, and S. J. Enna
International Union of Pharmacology. XXXIII. Mammalian gamma -Aminobutyric AcidB Receptors: Structure and Function
Pharmacol. Rev., June 1, 2002; 54(2): 247 - 264.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
L.-N. Cui, E. Coderre, and L. P. Renaud
Glutamate and GABA mediate suprachiasmatic nucleus inputs to spinal-projecting paraventricular neurons
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2001; 281(4): R1283 - R1289.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online