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Am J Physiol Regul Integr Comp Physiol 278: R1247-R1257, 2000;
0363-6119/00 $5.00
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Vol. 278, Issue 5, R1247-R1257, May 2000

Explicating hypergonadotropism in postmenopausal women: a statistical model

Daniel M. Keenan1 and Johannes D. Veldhuis2,3

1 Department of Statistics, 2 Division of Endocrinology, Health Sciences Center, 3 National Science Foundation Center for Biological Timing, University of Virginia, Charlottesville, Virginia 22908

Neurohormone secretion is viewed here as a variable (unknown) admixture of basal and pulsatile release mechanisms, convolved with individually fitted biexponential elimination kinetics. This construct allows maximum-likelihood estimates of both (regulated and constitutive) components of hormone secretion. Thereby, we infer that a prolonged slow-component half-life of gonadotropin removal and amplified pulsatile (and total) daily luteinizing hormone (LH) secretion rates jointly explicate the postmenopausal elevation in serum LH concentrations without a necessary rise in basal LH secretion rates. This biomathematical formulation should be useful in exploring other neuroregulatory mechanisms that underlie single or dual alterations in the basal versus pulsatile modes of hormone secretion.

gonadotropin; human; methods; statistics; age; analysis; luteinizing hormone


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