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Am J Physiol Regul Integr Comp Physiol 278: R1289-R1295, 2000;
0363-6119/00 $5.00
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Vol. 278, Issue 5, R1289-R1295, May 2000

Effects of abdominal or cardiopulmonary sympathetic afferents on upper cervical inspiratory neurons

Y. Yuan, M. J. Chandler, R. D. Foreman, and J. P. Farber

Department of Physiology, Univeristy of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73190

Responses of upper cervical inspiratory neurons (UCINs) to abdominal visceral or cardiopulmonary sympathetic stimulation were studied using extracellular recordings from 213 UCINs in 54 pentobarbital sodium-anesthetized and paralyzed rats. Phrenic nerve activity was used to assess inspiration. The UCINs discharging during inspiration only were mainly in the C1 segment, whereas phase-spanning UCINs were mostly in the C2 segment. Phase-spanning activity was typically retained after overventilation or vagotomy. When greater splanchnic nerve (GSN) or cardiopulmonary sympathetic afferent (CPSA) fibers were electrically stimulated, augmented UCIN activity was observed in 65% of cells responding to CPSA stimulation but in only 17% of cells responding to GSN. Response latencies were 10.7 ± 0.5 and 20.6 ± 1.5 (SE) ms, respectively. Many augmented responses to CPSA stimulation (64%) and all augmented responses to GSN stimulation were followed by suppression of UCIN discharge (biphasic response). Phrenic nerve activity was suppressed by both GSN and CPSA stimulation, but with shorter latency for the latter (29 ± 0.7 vs. 14.0 ± 0.7 ms). Excitation of UCINs using CPSA stimulation occurs more often and by a more direct pathway than for GSN input.

ansa subclavia; greater splanchnic nerve; spinal cord respiratory neurons; stellate ganglia


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