AJP - Regu AJP: Renal Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 278: R1391-R1400, 2000;
0363-6119/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (28)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bissonnette, J. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bissonnette, J. M.
Vol. 278, Issue 6, R1391-R1400, June 2000

INVITED REVIEW
Mechanisms regulating hypoxic respiratory depression during fetal and postnatal life

John M. Bissonnette

Departments of Obstetrics and Gynecology and Cell and Developmental Biology, Oregon Health Sciences University, Portland, Oregon 97201-3098

Selected topics in the respiratory response to acute hypoxia in the fetus and newborn are reviewed. Peripheral chemoreceptors acting through ionotrophic glutamate receptors play an important role in affecting the initial augmentation phase. Whether fall off in peripheral chemoreceptor activity contributes to the secondary depressive phase remains controversial. A number of approaches including permanent electrolytic and reversible cooling lesions, Fos protein activation, and double-labeling immunohistochemistry has converged to show that an area in and around the locus ceruleus in the rostral pons affects the central depression. There is evidence that this is mediated by catecholamines acting at alpha 2-adrenergic receptors. Tonic activity in early expiratory (postinspiratory) neurons may contribute to hypoxia-induced apneic episodes in the fetus and newborn. Desensitization of alpha -amino-3-hydroxy-5-methylisoxazole-4-proprionic acid receptors has been demonstrated in respiratory-related neurons both in vivo and in vitro. The role that this process might play in the depressive phase of the hypoxic ventilatory response has not been established. In vitro experiments with isolated brain stem-spinal cord preparations or transverse brain stem slices usually involve anoxia, whereas whole animal experiments use 8-15% O2. Therefore, caution must be exercised in attempting to construct a unifying framework from these two approaches.

biphasic ventilatory response; control of respiration; fetal breathing movements


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
R. W. Bavis and G. S. Mitchell
Long-term effects of the perinatal environment on respiratory control
J Appl Physiol, April 1, 2008; 104(4): 1220 - 1229.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. Julien, A. Bairam, and V. Joseph
Chronic intermittent hypoxia reduces ventilatory long-term facilitation and enhances apnea frequency in newborn rats
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2008; 294(4): R1356 - R1366.
[Abstract] [Full Text] [PDF]

Home page
 Integr. Comp. Biol.Home page
L. Sundin, M. L. Burleson, A. P. Sanchez, J. Amin-Naves, R. Kinkead, L. H. Gargaglioni, L. K. Hartzler, M. Wiemann, P. Kumar, and M. L. Glass
Respiratory chemoreceptor function in vertebrates comparative and evolutionary aspects
Integr. Comp. Biol., October 1, 2007; 47(4): 592 - 600.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
Q. Liu, T. F. Lowry, and M. T. T. Wong-Riley
Postnatal changes in ventilation during normoxia and acute hypoxia in the rat: implication for a sensitive period
J. Physiol., December 15, 2006; 577(3): 957 - 970.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
A. V Gourine
On the peripheral and central chemoreception and control of breathing: an emerging role of ATP
J. Physiol., November 1, 2005; 568(3): 715 - 724.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
B. J. Koos, Y. Kawasaki, Y.-H. Kim, and F. Bohorquez
Adenosine A2A-receptor blockade abolishes the roll-off respiratory response to hypoxia in awake lambs
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2005; 288(5): R1185 - R1194.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. V. Gourine, E. Llaudet, N. Dale, and K. M. Spyer
Release of ATP in the Ventral Medulla during Hypoxia in Rats: Role in Hypoxic Ventilatory Response
J. Neurosci., February 2, 2005; 25(5): 1211 - 1218.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. A. Neubauer and J. Sunderram
Oxygen-sensing neurons in the central nervous system
J Appl Physiol, January 1, 2004; 96(1): 367 - 374.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. Dauger, A. Pattyn, F. Lofaso, C. Gaultier, C. Goridis, J. Gallego, and J.-F. Brunet
Phox2b controls the development of peripheral chemoreceptors and afferent visceral pathways
Development, December 29, 2003; 130(26): 6635 - 6642.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
H. Scholz
Adaptational responses to hypoxia
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2002; 282(6): R1541 - R1543.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online