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Am J Physiol Regul Integr Comp Physiol 278: R1408-R1414, 2000;
0363-6119/00 $5.00
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Vol. 278, Issue 6, R1408-R1414, June 2000

Antipyretic effect of arginine vasotocin in toads

K. C. Bicego-Nahas1, A. A. Steiner1, E. C. Carnio2, J. Antunes-Rodrigues1, and L. G. S. Branco3

1 Faculdade de Medicina de Ribeirão Preto, 3 Faculdade de Odontologia de Ribeirão Preto, and 2 Escola de Enfermagem de Ribeirão Preto, Universidade de São Paulo, 14040-904 Ribeirão Preto, São Paulo, Brazil

Arginine vasotocin (AVT) is a nonmammalian analog of the mammalian hormone arginine vasopressin (AVP). These peptides are known for their antidiuretic and pressor effects. More recently, AVP has been recognized as an important antipyretic molecule in mammals. However, no information exists about the role of AVT in febrile ectotherms. We tested the hypothesis that AVT is an antipyretic molecule in the toad Bufo paracnemis. Toads equipped with a temperature probe were placed in a thermal gradient, and preferred body temperature was recorded continuously. A behavioral fever was observed after lipopolysaccharide (LPS) was injected systemically (200 µg/kg). Systemically injected AVT (300 pmol/kg) alone caused no significant change in body temperature, but abolished LPS-induced fever. Moreover, a smaller dose of AVT (10 pmol/kg), which did not affect LPS-induced fever when injected peripherally, abolished fever when injected intracerebroventricularly. We therefore conclude that AVT plays an antipyretic role in the central nervous system, by means of behavior, in an ectotherm, a fact consistent with the notion that AVT/AVP elicits antipyresis by reducing the thermoregulatory set point.

behavioral fever; antipyresis; body temperature; lipopolysaccharide; Bufo


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