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Am J Physiol Regul Integr Comp Physiol 278: R1453-R1459, 2000;
0363-6119/00 $5.00
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Vol. 278, Issue 6, R1453-R1459, June 2000

Ontogeny of neuronal nitric oxide synthase, NOS I, in the developing porcine kidney

Michael J. Solhaug1, Xui Q. Dong1, Raymond D. Adelman1, and Ke-Wen Dong2

1 Departments of Pediatrics, Physiology, and 2 Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk, Virginia 23507

To determine if the developing kidney differs from the adult in the expression of the neuronal nitric oxide synthase, NOS I, these experiments measured mRNA gene expression by RNase protection assay and protein content by Western blot of NOS I in piglets at ages newborn and 3, 7, 10, 14, and 21 days and adult pigs. Whole kidney NOS I mRNA was greatest at birth and decreased progressively during renal maturation to adult levels. NOS I protein content paralleled this developmental pattern. Cortical NOS I protein was equivalent in newborn and 14-day-old piglets and was greater at both ages than the adult. Medullary NOS I protein was relatively greater than cortical in both immature ages and decreased from a peak at birth to adult levels. We conclude the following. 1) During postnatal maturation, renal NOS I mRNA and protein content show a pattern that is developmentally regulated. 2) This developmental pattern of NOS I after birth may, in part, contribute to the enhanced functional role of NO during renal maturation.

development


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