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Am J Physiol Regul Integr Comp Physiol 278: R1651-R1660, 2000;
0363-6119/00 $5.00
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Vol. 278, Issue 6, R1651-R1660, June 2000

Mitogenic whey extract stimulates wound repair activity in vitro and promotes healing of rat incisional wounds

Timothy E. Rayner1, Allison J. Cowin1, J. Gray Robertson1, Rodney D. Cooter2, Richard C. Harries2, Geoffrey O. Regester1, Geoffrey W. Smithers3, Chris Goddard4, and David A. Belford4

1 Cooperative Research Centre for Tissue Growth and Repair, Child Health Research Institute, Women's and Children's Hospital, North Adelaide 5006; 2 Plastic and Reconstructive Surgery, University of Adelaide, Department of Surgery, The Queen Elizabeth Hospital, Woodville 5011; 4 Commonwealth Scientific and Industrial Research Organization Division of Human Nutrition, Adelaide BC 5000; and 3 Food Science Australia, Highett, Victoria 3190, Australia

The ability of single growth factors to promote healing of normal and compromised wounds has been well described, but wound healing is a process requiring the coordinated action of multiple growth factors. Only the synergistic effect on wound healing of combinations containing at most two individual growth factors has been reported. We sought to assess the ability of a novel milk-derived growth factor-enriched preparation [mitogenic bovine whey extract (MBWE)], which contains six known growth factors, to promote repair processes in organotypic in vitro models and incisional wounds in vivo. MBWE stimulated the contraction of fibroblast-populated collagen lattices in a dose-dependent fashion and promoted the closure of excisional wounds in embryonic day 17 fetal rat skin. Application of MBWE increased incisional wound strength in normal animals on days 3, 5, 7, and 10 and reversed the decrease in wound strength observed following steroid treatment. Wound histology showed increased fibroblast numbers in wounds from normal and steroid-compromised animals. These data suggest the mixture of factors present in bovine milk exerts a direct action on the cells of cutaneous wound repair to enhance both normal and compromised healing.

growth factor; wound healing; skin; fetal wound healing; fibroblast-populated collagen lattice


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