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Am J Physiol Regul Integr Comp Physiol 279: R132-R140, 2000;
0363-6119/00 $5.00
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Vol. 279, Issue 1, R132-R140, July 2000

Receptor subtypes mediating depressor responses to microinjections of nicotine into medial NTS of the rat

S. Dhar1, F. Nagy1, J. M. McIntosh2, and H. N. Sapru1

1 Department of Neurosurgery, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, New Jersey 07103; and 2 Departments of Biology and Psychiatry, University of Utah, Salt Lake City, Utah 84112

Microinjections (50 nl) of nicotine (0.01-10 µM) into the nucleus of the solitary tract (NTS) of adult, urethan-anesthetized, artificially ventilated, male Wistar rats, elicited decreases in blood pressure and heart rate. Prior microinjections of alpha -bungarotoxin (alpha -BT) and alpha -conotoxin ImI (specific toxins for nicotinic receptors containing alpha 7 subunits) elicited a 20-38% reduction in nicotine responses. Similarly, prior microinjections of hexamethonium, mecamylamine, and alpha -conotoxin AuIB (specific blockers or toxin for nicotinic receptors containing alpha 3beta 4 subunits) elicited a 47-79% reduction in nicotine responses. Nicotine responses were completely blocked by prior sequential microinjections of alpha -BT and mecamylamine into the NTS. Complete blockade of excitatory amino acid receptors (EAARs) in the NTS did not attenuate the responses to nicotine. It was concluded that 1) the predominant type of nicotinic receptor in the NTS contains alpha 3beta 4 subunits, 2) a smaller proportion contains alpha 7 subunits, 3) the presynaptic nicotinic receptors in the NTS do not contribute to nicotine-induced responses, and 4) EAARs in the NTS are not involved in mediating responses to nicotine.

blood pressure; bradycardia; heart rate; hexamethonium; mecamylamine


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