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1 Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense University, 5230 Odense M; 3 Institute of Clinical Research, Odense University Hospital, 5230 Odense M; 4 Copenhagen Muscle Research Centre, Rigshospitalet, DK-2200 Copenhagen N, Denmark; and 2 Institute for Experimental Medical Research, Ullevaal Hospital, 0407 Oslo, Norway
To evaluate
the effect of intermittent sprint training on sarcoplasmic
reticulum (SR) function, nine young men performed a 5 wk high-intensity
intermittent bicycle training, and six served as controls. SR function
was evaluated from resting vastus lateralis muscle biopsies,
before and after the training period. Intermittent sprint performance
(ten 8-s all-out periods alternating with 32-s recovery) was enhanced
12% (P < 0.01) after training. The 5-wk sprint training
induced a significantly higher (P < 0.05) peak rate of
AgNO3-stimulated Ca2+ release from 709 (range
560-877; before) to 774 (596-977) arbitrary units
Ca2+ · g
protein
1 · min1
(after). The relative SR density of functional ryanodine receptors (RyR) remained unchanged after training; there was, however, a 48%
(P < 0.05) increase in total number of RyR. No significant differences in Ca2+ uptake rate and Ca2+-ATPase
capacity were observed following the training, despite that the
relative density of Ca2+-ATPase isoforms SERCA1 and SERCA2
had increased 41% and 55%, respectively (P < 0.05). These
data suggest that high-intensity training induces an enhanced peak SR
Ca2+ release, due to an enhanced total volume of SR,
whereas SR Ca2+ sequestration function is not altered.
calcium; fatigue; ryanodine receptors; calcium-activated adenosinetriphosphatase; myosin heavy chain distribution
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