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Am J Physiol Regul Integr Comp Physiol 279: R222-R229, 2000;
0363-6119/00 $5.00
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Vol. 279, Issue 1, R222-R229, July 2000

Expression of a duplicate Na,K-ATPase beta 1-isoform in the European eel (Anguilla anguilla)

Christopher P. Cutler1, Stephane Brezillon1, Songul Bekir1, Ian L. Sanders1, Neil Hazon2, and Gordon Cramb1

1 School of Biology, Bute Medical Buildings, University of Saint Andrews, Saint Andrews, Fife, Scotland KY16 9TS; and 2 Gatty Marine Laboratory, University of Saint Andrews, Saint Andrews, Fife, Scotland KY16 8LB, United Kingdom

Recent studies on teleost fish have suggested that their genomes have undergone ancient polyploidization events resulting in the duplication of the genome. A duplicate copy of the Na,K-ATPase beta 1-isoform (called beta 233) has been identified in the European eel (Anguilla anguilla). The beta 233-isoform shares high levels of nucleotide (74.8%) and amino acid (69.9%) homology with the eel beta 1-subunit as well as other vertebrate beta 1-sequences. Compared with the widely expressed beta 1-isoform, expression of beta 233-mRNA is mainly restricted to epithelial tissues. Seawater acclimation induced increases in beta 233-mRNA levels in kidney, gill, and intestine of migratory "silver" but not the nonmigratory "yellow" adult eels, suggesting that the factors responsible for this upregulation are themselves developmentally regulated. Expression of a variably glycosylated 40- to 52-kDa beta 233-protein in both gill "chloride" and intestinal epithelial cells suggests that the beta 233-isoform of Na,K-ATPase may play an important functional role in the major osmoregulatory tissues of euryhaline fish such as the eel.

teleost fish; mRNA expression; salinity acclimation; developmental maturation; immunolocalization.


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