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1-isoform
in the European eel (Anguilla anguilla)
1 School of Biology, Bute Medical Buildings, University of Saint Andrews, Saint Andrews, Fife, Scotland KY16 9TS; and 2 Gatty Marine Laboratory, University of Saint Andrews, Saint Andrews, Fife, Scotland KY16 8LB, United Kingdom
Recent studies on
teleost fish have suggested that their genomes have undergone ancient
polyploidization events resulting in the duplication of the genome. A
duplicate copy of the Na,K-ATPase 
1-isoform (called
233) has been identified in the European eel (Anguilla anguilla). The 233-isoform shares
high levels of nucleotide (74.8%) and amino acid (69.9%) homology
with the eel 1-subunit as well as other vertebrate
1-sequences. Compared with the widely expressed
1-isoform, expression of 233-mRNA is
mainly restricted to epithelial tissues. Seawater acclimation induced
increases in 233-mRNA levels in kidney, gill, and
intestine of migratory "silver" but not the nonmigratory
"yellow" adult eels, suggesting that the factors responsible for
this upregulation are themselves developmentally regulated. Expression
of a variably glycosylated 40- to 52-kDa 233-protein in
both gill "chloride" and intestinal epithelial cells suggests that
the 233-isoform of Na,K-ATPase may play an important
functional role in the major osmoregulatory tissues of euryhaline fish
such as the eel.
teleost fish; mRNA expression; salinity acclimation; developmental maturation; immunolocalization.
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