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Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260
Rats with chronic
nucleus of the solitary tract lesions (NTS-X) drink water and release
vasopressin (VP) in response to reduced blood volume despite an absence
of neural signals from cardiac and arterial baroreceptors. The present
study determined whether rats with NTS-X have a greater sensitivity to
circulating ANG II, which may contribute to the drinking and VP
responses to hypovolemia. In conscious control rats and rats with
NTS-X, ANG II was infused intravenously for 1 h at 10, 100, or 250 ng · kg
1 · min1. At the two
higher doses, ANG II stimulated more water intake with a shorter
latency to drink in rats with NTS-X than in control rats. In contrast,
infusion of ANG II produced comparable increases in plasma VP in the
two groups. At the two higher doses, ANG II produced an enhanced
increase in arterial pressure (AP) in rats with NTS-X, and the
bradycardia seen in control rats was reversed to a tachycardia.
Infusion of hypertonic saline, which did not alter AP or heart rate,
produced comparable drinking and VP release in the two groups. These
results demonstrate that chronic NTS-X increases the dipsogenic
response of rats to systemic ANG II but has no effect on ANG II-induced
VP release or the osmotic stimulation of these responses.
baroreceptors; arterial pressure; thirst; hypertonic saline
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