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Departments of 1 Obstetrics and Gynecology, 2 Physiology and Pharmacology, and the Perinatal Research Laboratories, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157
To determine the role of
the renal nerves on renin secretion and expression in the mature ovine
fetus, we performed bilateral renal denervation on eight fetuses of
time-dated pregnant ewes (126.8 ± 0.6 days gestation) and
compared renin in them to seven fetuses that underwent sham denervation
(126.7 ± 0.6 days gestation). Fetal arterial and venous catheters
were implanted, and after 5-7 days of recovery isoproterenol was
infused. Plasma active renin was lower in denervated animals than in
intact animals under basal conditions and at each dose of
isoproterenol. Plasma prorenin levels were lower in denervated fetuses
but unaffected by isoproterenol. Denervation did not change renal
renin, prorenin, or renin mRNA, but it did block isoproterenol-induced
increases in renin mRNA in renocortical cells in vitro. We conclude
that the renal nerves are required for renin secretory mechanisms and
responsiveness of renin mRNA to 
-adrenergic stimulation but not for
the expression of renin in the fetal kidney. We propose that one or
more of the factors that maintain renin expression in the perinatal
period may be absent or may be replaced by the renal nerves in the adult.
kidney; development; beta adrenergic stimulation
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J. S. Rosnes, N. Valego, J. J. Wang, F. M. Perez, and J. C. Rose Renal mRNA response to reduced perfusion pressure conserved despite denervation in mature ovine fetuses Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2001; 280(6): R1830 - R1836. [Abstract] [Full Text] [PDF]
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