AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 279: R349-R354, 2000;
0363-6119/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (21)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Frank, S. M.
Right arrow Articles by Goldstein, D. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Frank, S. M.
Right arrow Articles by Goldstein, D. S.
Vol. 279, Issue 1, R349-R354, July 2000

Age-related thermoregulatory differences during core cooling in humans

Steven M. Frank1, Srinivasa N. Raja1, Christian Bulcao2, and David S. Goldstein3

1 Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore 21287; 3 Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892; and 2 McGill University School of Medicine, Montreal, Quebec, Canada H2X 3R2

The current study assessed sympathetic neuronal and vasomotor responses, total body oxygen consumption, and sensory thermal perception to identify thermoregulatory differences in younger and older human subjects during core cooling. Cold fluid (40 ml/kg, 4°C) was given intravenously over 30 min to decrease core temperature (Tc) in eight younger (age 18-23) and eight older (age 55-71) individuals. Compared with younger subjects, the older subjects had significantly lower Tc thresholds for vasoconstriction (35.5 ± 0.3 vs. 36.2 ± 0.2°C, P = 0.03), heat production (35.2 ± 0.4 vs. 35.9 ± 0.1°C, P = 0.04), and plasma norepinephrine (NE) responses (35.0 vs. 36.0°C, P < 0.05). Despite a lower Tc nadir during cooling, the maximum intensities of the vasoconstriction (P = 0.03) and heat production (P = 0.006) responses were less in the older compared with the younger subjects, whereas subjective thermal comfort scores were similar. Plasma NE concentrations increased fourfold in the younger but only twofold in the older subjects at maximal Tc cooling. The vasomotor response for a given change in plasma NE concentration was decreased in the older group (P = 0.01). In summary, aging is associated with 1) a decreased Tc threshold and maximum response intensity for vasoconstriction, total body oxygen consumption, and NE release, 2) decreased vasomotor responsiveness to NE, and 3) decreased subjective sensory thermal perception.

epinephrine; heat production; norepinephrine regulation; temperature vasoconstriction


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
M. A. Neimark, A.-A. Konstas, A. F. Laine, and J. Pile-Spellman
Integration of jugular venous return and circle of Willis in a theoretical human model of selective brain cooling
J Appl Physiol, November 1, 2007; 103(5): 1837 - 1847.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
E. J. W. Van Someren
Thermoregulation and aging
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R99 - R102.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
D. W. DeGroot and W. L. Kenney
Impaired defense of core temperature in aged humans during mild cold stress
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R103 - R108.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
V. Srinivasan, V. M. Nadkarni, D. Yannopoulos, B. S. Marino, G. Sigurdsson, S. H. McKnite, M. Zook, D. G. Benditt, and K. G. Lurie
Rapid Induction of Cerebral Hypothermia Is Enhanced With Active Compression-Decompression Plus Inspiratory Impedance Threshold Device Cardiopulmonary Resusitation in a Porcine Model of Cardiac Arrest
J. Am. Coll. Cardiol., February 21, 2006; 47(4): 835 - 841.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
A. Wadhwa, P. Sengupta, J. Durrani, O. Akca, R. Lenhardt, D. I. Sessler, and A. G. Doufas
Magnesium sulphate only slightly reduces the shivering threshold in humans
Br. J. Anaesth., June 1, 2005; 94(6): 756 - 762.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. S. Thompson, L. A. Holowatz, and W. L. Kenney
Cutaneous vasoconstrictor responses to norepinephrine are attenuated in older humans
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2005; 288(5): R1108 - R1113.
[Abstract] [Full Text] [PDF]

Home page
 Arch SurgHome page
O. O. Aalami, T. D. Fang, H. M. Song, and R. P. Nacamuli
Physiological Features of Aging Persons
Arch Surg, October 1, 2003; 138(10): 1068 - 1076.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
G. F. DiBona
Thermoregulation
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2003; 284(2): R277 - R279.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. Nagashima, T. Yoda, T. Yagishita, A. Taniguchi, T. Hosono, and K. Kanosue
Thermal regulation and comfort during a mild-cold exposure in young Japanese women complaining of unusual coldness
J Appl Physiol, March 1, 2002; 92(3): 1029 - 1035.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. B. Persson
Aging
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2002; 282(1): R1 - R2.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online