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Am J Physiol Regul Integr Comp Physiol 279: R448-R454, 2000;
0363-6119/00 $5.00
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Vol. 279, Issue 2, R448-R454, August 2000

Role of potassium channels in catecholamine secretion in the rat adrenal gland

Takahiro Nagayama1, Yasuo Fukushima1, Makoto Yoshida1, Mizue Suzuki-Kusaba1, Hiroaki Hisa1, Tomohiko Kimura2, and Susumu Satoh1

1 Laboratory of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aobayama, Sendai 980-8578; and 2 Department of Dental Pharmacology, The Nippon Dental University School of Dentistry at Niigata, Hamaura-cho, Niigata 951-8580, Japan

We elucidated the functional contribution of K+ channels to cholinergic control of catecholamine secretion in the perfused rat adrenal gland. The small-conductance Ca2+-activated K+ (SKCa)-channel blocker apamin (10-100 nM) enhanced the transmural electrical stimulation (ES; 1-10 Hz)- and 1,1-dimethyl-4-phenyl-piperazinium (DMPP; 5-40 µM)-induced increases in norepinephrine (NE) output, whereas it did not affect the epinephrine (Epi) responses. Apamin enhanced the catecholamine responses induced by acetylcholine (6-200 µM) and methacholine (10-300 µM). The putative large-conductance Ca2+-activated K+ channel blocker charybdotoxin (10-100 nM) enhanced the catecholamine responses induced by ES, but not the responses induced by cholinergic agonists. Neither the KA channel blocker mast cell degranulating peptide (100-1000 nM) nor the KV channel blocker margatoxin (10-100 nM) affected the catecholamine responses. These results suggest that SKCa channels play an inhibitory role in adrenal catecholamine secretion mediated by muscarinic receptors and also in the nicotinic receptor-mediated secretion of NE, but not of Epi. Charybdotoxin-sensitive Ca2+-activated K+ channels may control the secretion at the presynaptic site.

small-conductance Ca2+-activated K+; large-conductance Ca2+-activated K+; KA channel; KV channel; apamin; charybdotoxin; mast cell degranulating peptide; margatoxin


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 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
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 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
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