AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 279: R461-R467, 2000;
0363-6119/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (27)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Moon, J.-H.
Right arrow Articles by Terao, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Moon, J.-H.
Right arrow Articles by Terao, J.
Vol. 279, Issue 2, R461-R467, August 2000

Accumulation of quercetin conjugates in blood plasma after the short-term ingestion of onion by women

Jae-Hak Moon1, Ritsuko Nakata2, Syunji Oshima3, Takahiro Inakuma3, and Junji Terao1

1 Department of Nutrition, School of Medicine, The University of Tokushima, Tokushima 770-8503; 2 Department of Nursing, School of Medical Sciences, The University of Tokushima, Tokushima 770-8509; and 3 Kagome Research Institute, Kagome Company, Nishinasuno, Tochigi 329-2762, Japan

Quercetin is a typical flavonoid present mostly as glycosides in plant foods; it has attracted much attention for its potential beneficial effects in disease prevention. In this study, we examined human volunteers after the short-term ingestion of onion, a vegetable rich in quercetin glucosides. The subjects were served diets containing onion slices (quercetin equivalent: 67.6-93.6 mg/day) with meals for 1 wk. Quercetin was only found in glucuronidase-sulfatase-treated plasma, and its concentration after 10 h of fasting increased from 0.04 ± 0.04 µM before the trial to 0.63 ± 0.72 µM after the 1-wk trial. The quercetin content in low-density lipoprotein (LDL) after glucuronidase-sulfatase treatment corresponded to <1% of the alpha -tocopherol content. Human LDL isolated from the plasma after the trial showed little improvement of its resistance to copper ion-induced oxidation. It is therefore concluded that conjugated metabolites of quercetin accumulate exclusively in human blood plasma in the concentration range of 10-7 ~ 10-6 M after the short-term ingestion of vegetables rich in quercetin glucosides, although these metabolites are hardly incorporated into plasma LDL.

quercetin metabolites; quercetin glycosides; low-density lipoprotein oxidation; glucuronidation


This article has been cited by other articles:


Home page
 J. Nutr.Home page
M. Amasheh, S. Schlichter, S. Amasheh, J. Mankertz, M. Zeitz, M. Fromm, and J. D. Schulzke
Quercetin Enhances Epithelial Barrier Function and Increases Claudin-4 Expression in Caco-2 Cells
J. Nutr., June 1, 2008; 138(6): 1067 - 1073.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
C. Manach, G. Williamson, C. Morand, A. Scalbert, and C. Remesy
Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
Am. J. Clinical Nutrition, January 1, 2005; 81(1): 230S - 242S.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
P. A Kroon, M. N Clifford, A. Crozier, A. J Day, J. L Donovan, C. Manach, and G. Williamson
How should we assess the effects of exposure to dietary polyphenols in vitro?
Am. J. Clinical Nutrition, July 1, 2004; 80(1): 15 - 21.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
K. Murota, S. Shimizu, S. Miyamoto, T. Izumi, A. Obata, M. Kikuchi, and J. Terao
Unique Uptake and Transport of Isoflavone Aglycones by Human Intestinal Caco-2 Cells: Comparison of Isoflavonoids and Flavonoids
J. Nutr., July 1, 2002; 132(7): 1956 - 1961.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
A. L. A. Sesink, K. A. O'Leary, and P. C. H. Hollman
Quercetin Glucuronides but Not Glucosides Are Present in Human Plasma after Consumption of Quercetin-3-Glucoside or Quercetin-4'-Glucoside
J. Nutr., July 1, 2001; 131(7): 1938 - 1941.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online