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Am J Physiol Regul Integr Comp Physiol 279: R461-R467, 2000;
0363-6119/00 $5.00
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Vol. 279, Issue 2, R461-R467, August 2000

Accumulation of quercetin conjugates in blood plasma after the short-term ingestion of onion by women

Jae-Hak Moon1, Ritsuko Nakata2, Syunji Oshima3, Takahiro Inakuma3, and Junji Terao1

1 Department of Nutrition, School of Medicine, The University of Tokushima, Tokushima 770-8503; 2 Department of Nursing, School of Medical Sciences, The University of Tokushima, Tokushima 770-8509; and 3 Kagome Research Institute, Kagome Company, Nishinasuno, Tochigi 329-2762, Japan

Quercetin is a typical flavonoid present mostly as glycosides in plant foods; it has attracted much attention for its potential beneficial effects in disease prevention. In this study, we examined human volunteers after the short-term ingestion of onion, a vegetable rich in quercetin glucosides. The subjects were served diets containing onion slices (quercetin equivalent: 67.6-93.6 mg/day) with meals for 1 wk. Quercetin was only found in glucuronidase-sulfatase-treated plasma, and its concentration after 10 h of fasting increased from 0.04 ± 0.04 µM before the trial to 0.63 ± 0.72 µM after the 1-wk trial. The quercetin content in low-density lipoprotein (LDL) after glucuronidase-sulfatase treatment corresponded to <1% of the alpha -tocopherol content. Human LDL isolated from the plasma after the trial showed little improvement of its resistance to copper ion-induced oxidation. It is therefore concluded that conjugated metabolites of quercetin accumulate exclusively in human blood plasma in the concentration range of 10-7 ~ 10-6 M after the short-term ingestion of vegetables rich in quercetin glucosides, although these metabolites are hardly incorporated into plasma LDL.

quercetin metabolites; quercetin glycosides; low-density lipoprotein oxidation; glucuronidation


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