AJP - Regu Add DOIs to your references at manuscript stage!
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 279: R548-R553, 2000;
0363-6119/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (11)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Eliakim, A.
Right arrow Articles by Cooper, D. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Eliakim, A.
Right arrow Articles by Cooper, D. M.
Vol. 279, Issue 2, R548-R553, August 2000

Effect of single wrist exercise on fibroblast growth factor-2, insulin-like growth factor, and growth hormone

Alon Eliakim1, Youngman Oh2, and Dan Michael Cooper1

1 Department of Pediatrics, University of California, College of Medicine, Irvine, California 92868; and Department of 2 Pediatrics, Oregon Health Sciences University, Portland, Oregon 97201

Anabolic effects of exercise are mediated, in part, by fibroblast growth factor-2 (FGF-2), insulin-like growth factor-I (IGF-I), and growth hormone (GH). To identify local vs. systemic modification of these mediators, 10 male subjects performed 10 min of unilateral wrist-flexion exercise. Blood was sampled from catheters placed in basilic veins of both arms. Lactate was significantly increased only in the exercising arm. FGF-2 decreased dramatically (P < 0.01) in both the resting (from 1.49 ± 0.32 to nadir at 0.11 ± 0.11 pg/ml) and exercising arm (1.80 ± 0.60 to 0.29 ± 0.14 pg/ml). Small but significant increases were found in both the resting and exercising arm for IGF-I and IGF binding protein-3 (IGFBP-3). GH was elevated in blood sampled from both the resting (from 1.04 ± 0.68 to a peak of 2.57 ± 0.53 ng/ml) and exercising arm (1.04 ± 0.66 to 2.43 ± 0.42 ng/ml, P < 0.05). Unilateral wrist exercise was not sufficiently intense to increase circulating lactate or heart rate, but it led to systemic changes in GH, IGF-I, IGFBP-3, and FGF-2. Low-intensity exercise involving small muscle groups can influence the circulating levels of growth factors.

growth factors; training; hypertrophy


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
D. Nemet, A. Eliakim, F. Zaldivar, and D. M. Cooper
Effect of rhIL-6 infusion on GH->IGF-I axis mediators in humans
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2006; 291(6): R1663 - R1668.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. Nemet, S. Hong, P. J. Mills, M. G. Ziegler, M. Hill, and D. M. Cooper
Systemic vs. local cytokine and leukocyte responses to unilateral wrist flexion exercise
J Appl Physiol, August 1, 2002; 93(2): 546 - 554.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. Schnermann
Exercise
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2002; 283(1): R2 - R6.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online