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1 Department of Physiology, Monash University, Victoria, Australia 3168; and 2 Department of Pathology, National University of Singapore, Singapore 0511
The diversity of
renal arteriole diameters in different cortical regions has important
consequences for control of glomerular capillary pressure. We examined
whether intrarenal angiotensin II (ANG II; 0.1, 1, or 5 ng · kg
1 · min1) in anesthetized rabbits
acts preferentially on pre- or postglomerular vessels using vascular
casting. ANG II produced dose-related reductions in afferent
and efferent diameters in the outer, mid, and inner cortex, without
effecting arterial pressure. Afferent diameter decreased more than
efferent in the outer and mid cortex (P < 0.05) but by
a similar extent in juxtamedullary nephrons (P = 0.58).
Calculated efferent resistance increased more than afferent, especially
in the outer cortex (127 vs. 24 units; 5 ng · kg1 · min1 ANG II). ANG II produced
significant dose-related increases in the distance between the
arterioles at the entrance to the glomerular pole in all regions. Thus
afferent diameter decreased more in response to ANG II, but efferent
resistance rose more due to smaller resting luminal dimensions.
The results also indicate that glomerular pole dimensions change in
response to ANG II.
juxtamedullary; kidney; mesangium; renal vascular resistance; vascular casting
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