| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
-MSH on food
intake, adiposity, c-Fos induction, and neuropeptide
expression
1 Program in Nutritional Sciences, Departments of 2 Psychiatry and Behavioral Sciences and 6 Medicine, University of Washington, Seattle 98195, 3 Puget Sound Veterans Affairs Health Care System, Seattle 98108, 7 Harborview Medical Center, Seattle, Washington 98104; 4 Department of Nutrition, University of California at Davis, Davis, California 95616; and 5 Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45267
-Melanocyte-stimulating hormone (-MSH) is a hypothalamic
neuropeptide proposed to play a key role in energy homeostasis. To
investigate the behavioral, metabolic, and hypothalamic responses to
chronic central -MSH administration, -MSH was infused
continuously into the third cerebral ventricle of rats for 6 days.
Chronic -MSH infusion reduced cumulative food intake by 10.7%
(P < 0.05 vs. saline) and body weight by 4.3%
(P < 0.01 vs. saline), which in turn lowered plasma
insulin levels by 29.3% (P < 0.05 vs. saline). However, -MSH did not cause adipose-specific wasting nor did it
alter hypothalamic neuropeptide mRNA levels. Central -MSH infusion
acutely activated neurons in forebrain areas such as the hypothalamic
paraventricular nucleus, as measured by a 254% increase in c-Fos-like
immunoreactivity (P < 0.01 vs. saline), as well as
satiety pathways in the hindbrain. Our findings suggest that, although
an increase of central melanocortin receptor signaling acutely reduces
food intake and body weight, its anorectic potency wanes during chronic
infusion and causes only a modest decrease of body weight.
melanocortin; hypothalamus; body weight
This article has been cited by other articles:
|
|
 |
|
  V. Tolle and M. J. Low In Vivo Evidence for Inverse Agonism of Agouti-Related Peptide in the Central Nervous System of Proopiomelanocortin-Deficient Mice Diabetes, January 1, 2008; 57(1): 86 - 94. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Lee, A. Kim, S. C. Chua Jr., S. Obici, and S. L. Wardlaw Transgenic MSH overexpression attenuates the metabolic effects of a high-fat diet Am J Physiol Endocrinol Metab, July 1, 2007; 293(1): E121 - E131. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Li, Y. Zhang, E. Rodrigues, D. Zheng, M. Matheny, K.-Y. Cheng, and P. J. Scarpace Melanocortin activation of nucleus of the solitary tract avoids anorectic tachyphylaxis and induces prolonged weight loss Am J Physiol Endocrinol Metab, July 1, 2007; 293(1): E252 - E258. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. D. Morrison, G. J. Morton, K. D. Niswender, R. W. Gelling, and M. W. Schwartz Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that requires phosphatidylinositol 3-OH-kinase signaling Am J Physiol Endocrinol Metab, December 1, 2005; 289(6): E1051 - E1057. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L.J. Ellacott and R. D. Cone The Central Melanocortin System and the Integration of Short- and Long-term Regulators of Energy Homeostasis Recent Prog. Horm. Res., January 1, 2004; 59(1): 395 - 408. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. Randich, P. C. Chandler, H. C. Mebane, M. E. Turnbach, S. T. Meller, G. R. Kelm, and J. E. Cox Jejunal administration of linoleic acid increases activity of neurons in the paraventricular nucleus of the hypothalamus Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2004; 286(1): R166 - R173. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X.-Y. Lu, G. S. Barsh, H. Akil, and S. J. Watson Interaction between {alpha}-Melanocyte-Stimulating Hormone and Corticotropin-Releasing Hormone in the Regulation of Feeding and Hypothalamo-Pituitary-Adrenal Responses J. Neurosci., August 27, 2003; 23(21): 7863 - 7872. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Li, C. V. Mobbs, and P. J. Scarpace Central Pro-opiomelanocortin Gene Delivery Results in Hypophagia, Reduced Visceral Adiposity, and Improved Insulin Sensitivity in Genetically Obese Zucker Rats Diabetes, August 1, 2003; 52(8): 1951 - 1957. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. E. Lohmeier, S. Warren, and J. T. Cunningham Sustained Activation of the Central Baroreceptor Pathway in Obesity Hypertension Hypertension, July 1, 2003; 42(1): 96 - 102. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Swart, J. W. Jahng, J. M. Overton, and T. A. Houpt Hypothalamic NPY, AGRP, and POMC mRNA responses to leptin and refeeding in mice Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2002; 283(5): R1020 - R1026. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. F. DiBona Neuropeptide Y Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2002; 282(3): R635 - R636. [Full Text] [PDF]
|
|
|
|
|
|
P. K. Olszewski, M. M. Wirth, T. J. Shaw, M. K. Grace, C. J. Billington, S. Q. Giraudo, and A. S. Levine Role of {alpha}-MSH in the regulation of consummatory behavior: immunohistochemical evidence Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2001; 281(2): R673 - R680. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
