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Am J Physiol Regul Integr Comp Physiol 279: R1025-R1034, 2000;
0363-6119/00 $5.00
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Vol. 279, Issue 3, R1025-R1034, September 2000

Regulation of food intake by neuropeptide Y in goldfish

Yuwaraj K. Narnaware1, Pierre P. Peyon2, Xinwei Lin1, and Richard E. Peter1

1 Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada T6G 2E9; and 2 Laboratory de Physiologie Generale et Comparee Museum National d'Histoire Naturalle, Unité de Recherche Associée 90 Centre National de la Recherche Scientifique, 75005 Paris, France

In mammals, neuropeptide Y (NPY) is a potent orexigenic factor. In the present study, third brain ventricle (intracerebroventricular) injection of goldfish NPY (gNPY) caused a dose-dependent increase in food intake in goldfish, and intracerebroventricular administration of NPY Y1-receptor antagonist BIBP-3226 decreased food intake; the actions of gNPY were blocked by simultaneous injection of BIBP-3226. Goldfish maintained on a daily scheduled feeding regimen display an increase in NPY mRNA levels in the telencephalon-preoptic area and hypothalamus shortly before feeding; however, a decrease occured in optic tectum-thalamus. In both fed and unfed fish, brain NPY mRNA levels decreased after scheduled feeding. Restriction in daily food ration intake for 1 wk or food deprivation for 72 h resulted in increased brain NPY mRNA levels. Results from these studies demonstrate that NPY is a physiological brain signal involved in feeding behavior in goldfish, mediating its effects, at least in part, through Y1-like receptors in the brain.

feeding; gene expression; growth hormone; brain


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