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Am J Physiol Regul Integr Comp Physiol 279: R997-R1009, 2000;
0363-6119/00 $5.00
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Vol. 279, Issue 3, R997-R1009, September 2000

Differential effects of selective vagotomy and tropisetron in aminoprivic feeding

Kimberly D. Dixon1, Fred E. Williams2, Raymond L. Wiggins2, Jason Pavelka2, James Lucente2, Larry L. Bellinger2, and Dorothy W. Gietzen1

1 Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine and Food Intake Laboratory, University of California, Davis, California 95616; and 2 Baylor College of Dentistry, Texas A&M University System Health Sciences Center, Department of Biological Sciences, Dallas, Texas 75246

Both total subdiaphragmatic vagotomy (TVAGX) and serotonin3 receptor blockade with tropisetron or ondansetron attenuate amino acid-imbalanced diet (Imb) anorexia. Total vagotomy is less effective than tropisetron in reducing Imb-induced anorexia and also blunts the tropisetron effect. With the use of electrocautery at the subdiaphragmatic level of the vagus, we severed the ventral and dorsal trunks as well as the hepatic, ventral gastric, dorsal gastric, celiac, and accessory celiac branches separately or in combination to determine which vagal branches or associated structures may be involved in these responses. Rats were prefed a low-protein diet. On the first experimental day, tropisetron or saline was given intraperitoneally 1 h before presentation of Imb. Cuts including the ventral branch, i.e., TVAGX, ventral vagotomy (above the hepatic branch), and hepatic + gastric vagotomies (but not hepatic branch cuts alone) caused the highest (P < 0.05) Imb intake on day 1 with or without tropisetron. The responses to tropisetron were not affected significantly. On days 2-8, groups having vagotomies that included the hepatic branch recovered faster than sham-treated animals. Because the hepatic and gastric branches together account for most of the vagal innervation to the proximal duodenum, this area may be important in the initial responses, whereas structures served by the hepatic branch alone apparently act in the later adaptation to Imb.

amino acid; diet; amino acid-imbalanced diet; amino acid deficiency; rat; food intake; body weight; vagus; serotonin


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