| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Departments of 1 Physiology and Pharmacology, 2 Medicine (Cardiology), 4 Pediatrics (Pediatric Cardiology), and 5 Obstetrics and Gynecology and 3 the Heart Research Center, Oregon Health Sciences University, Portland, Oregon 97201 - 3098
The effects of right ventricular (RV) systolic pressure (RVSP) load on fetal myocyte size and maturation were studied. Pulmonary artery (PA) pressure was increased by PA occlusion from mean 47.4 ± 5.0 (±SD) to 71 ± 13.6 mmHg (P < 0.0001) in eight RVSP-loaded near-term fetal sheep for 10 days. The maximal pressure generated by the RV with acute PA occlusion increased after RVSP load: 78 ± 7 to 101 ± 15 mmHg (P < 0.005). RVSP-load hearts were heavier (44.7 ± 8.4 g) than five nonloaded hearts (31.8 ± 0.2 g; P < 0.03); heart-to-body weight ratio (10.9 ± 1.1 and 6.5 ± 0.9 g/kg, respectively; P < 0.0001). RVSP-RV myocytes were longer (101.3 ± 10.2 µm) than nonloaded RV myocytes (88.2 ± 8.1 µm; P < 0.02) and were more often binucleated (82 ± 13%) than nonloaded myocytes (63 ± 7%; P < 0.02). RVSP-loaded myocytes had less myofibrillar volume than did nonloaded hearts (44.1 ± 4.4% and 56.1 ± 2.6%; P < 0.002). We conclude that RV systolic load 1) leads to RV myocyte enlargement, 2) has minor effects on left ventricular myocyte size, and 3) stimulates maturation (increased RV myocyte binucleation). Myocyte volume data suggest that RV systolic loading stimulates both hyperplastic and hypertrophic growth.
fetal cardiac function; myocyte growth; cytomorphometry
This article has been cited by other articles:
|
|
 |
|
  P. D. Gluckman, M. A. Hanson, C. Cooper, and K. L. Thornburg Effect of In Utero and Early-Life Conditions on Adult Health and Disease N. Engl. J. Med., July 3, 2008; 359(1): 61 - 73. [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Morrison, K. J. Botting, J. L. Dyer, S. J. Williams, K. L. Thornburg, and I. C. McMillen Restriction of placental function alters heart development in the sheep fetus Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2007; 293(1): R306 - R313. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Louey, S. S. Jonker, G. D. Giraud, and K. L. Thornburg Placental insufficiency decreases cell cycle activity and terminal maturation in fetal sheep cardiomyocytes J. Physiol., April 15, 2007; 580(2): 639 - 648. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. S. Jonker, L. Zhang, S. Louey, G. D. Giraud, K. L. Thornburg, and J. J. Faber Myocyte enlargement, differentiation, and proliferation kinetics in the fetal sheep heart J Appl Physiol, March 1, 2007; 102(3): 1130 - 1142. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Jonker, J. J. Faber, D. F. Anderson, K. L. Thornburg, S. Louey, and G. D. Giraud Sequential growth of fetal sheep cardiac myocytes in response to simultaneous arterial and venous hypertension Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2007; 292(2): R913 - R919. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Bubb, M. L. Cock, M. J. Black, M. Dodic, W.-M. Boon, H. C. Parkington, R. Harding, and M. Tare Intrauterine growth restriction delays cardiomyocyte maturation and alters coronary artery function in the fetal sheep J. Physiol., February 1, 2007; 578(3): 871 - 881. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. D. Giraud, J. J. Faber, S. S. Jonker, L. Davis, and D. F. Anderson Effects of intravascular infusions of plasma on placental and systemic blood flow in fetal sheep Am J Physiol Heart Circ Physiol, December 1, 2006; 291(6): H2884 - H2888. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. N. Spencer, K. J. Botting, J. L. Morrison, and G. S. Posterino Contractile and Ca2+-handling properties of the right ventricular papillary muscle in the late-gestation sheep fetus J Appl Physiol, September 1, 2006; 101(3): 728 - 733. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Olson, K. N. Protheroe, J. L. Segar, and T. D. Scholz Mitogen-activated protein kinase activation and regulation in the pressure-loaded fetal ovine heart Am J Physiol Heart Circ Physiol, April 1, 2006; 290(4): H1587 - H1595. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H M Gardiner Response of the fetal heart to changes in load: from hyperplasia to heart failure Heart, July 1, 2005; 91(7): 871 - 873. [Full Text] [PDF]
|
|
|
|
 |
|
 I. C. Mcmillen and J. S. Robinson Developmental Origins of the Metabolic Syndrome: Prediction, Plasticity, and Programming Physiol Rev, April 1, 2005; 85(2): 571 - 633. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. R. Lumbers, A. C. Boyce, G. Joulianos, V. Kumarasamy, E. Barner, J. L. Segar, and J. H. Burrell Effects of cortisol on cardiac myocytes and on expression of cardiac genes in fetal sheep Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2005; 288(3): R567 - R574. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Zhang Prenatal Hypoxia and Cardiac Programming Reproductive Sciences, January 1, 2005; 12(1): 2 - 13. [Abstract] [PDF]
|
|
|
|
 |
|
 K. L. Thornburg Fetal Origins of Cardiovascular Disease NeoReviews, December 1, 2004; 5(12): e527 - e533. [Full Text] [PDF]
|
|
|
|
|
|
N. C. Sundgren, G. D. Giraud, J. M. Schultz, M. R. Lasarev, P. J. S. Stork, and K. L. Thornburg Extracellular signal-regulated kinase and phosphoinositol-3 kinase mediate IGF-1 induced proliferation of fetal sheep cardiomyocytes Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2003; 285(6): R1481 - R1489. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Granger Maternal and fetal adaptations during pregnancy: lessons in regulatory and integrative physiology Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2002; 283(6): R1289 - R1292. [Full Text] [PDF]
|
|
|
|
|
|
J. L. Segar, G. B. Dalshaug, K. A. Bedell, O. M. Smith, and T. D. Scholz Angiotensin II in cardiac pressure-overload hypertrophy in fetal sheep Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2001; 281(6): R2037 - R2047. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. B. Dalshaug, T. D. Scholz, O. M. Smith, K. A. Bedell, C. A. Caldarone, and J. L. Segar Effects of gestational age on myocardial blood flow and coronary flow reserve in pressure-loaded ovine fetal hearts Am J Physiol Heart Circ Physiol, April 1, 2002; 282(4): H1359 - H1369. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
