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Am J Physiol Regul Integr Comp Physiol 279: R1205-R1214, 2000;
0363-6119/00 $5.00
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Vol. 279, Issue 4, R1205-R1214, October 2000

Metabolic depression and enhanced O2 affinity of mitochondria in hypoxic hypometabolism

Julie St-Pierre, Glenn J. Tattersall, and Robert G. Boutilier

Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, United Kingdom

This study examined whether the steady-state hypometabolism seen in overwintering frogs (Rana temporaria) is reflected at the mitochondrial level either by a reduction in their resting (state 4) and active (state 3) respiration rates and/or by increases in O2 affinity. We isolated mitochondria from the skeletal muscle of cold-submerged frogs at different stages during their hibernation in normoxic and hypoxic water. A modest metabolic depression at the whole animal level (normoxic submergence) was not associated with a reduction in mitochondrial state 4 and state 3 respiration rates. However, mitochondria isolated from frogs that were submerged for 1 mo manifested an increase in their O2 affinity compared with controls and with animals submerged for 4 mo. Hypometabolism was more pronounced at the whole animal level during hypoxic submergence and was accompanied by 1) a reduction in mitochondrial state 4 and state 3 rates and 2) an increase in the O2 affinity of mitochondria. These findings demonstrate that metabolic depression can be reflected at all levels of biological organization in hypoxia-tolerant animals.

frog; hypoxia; state 3; state 4; P50


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