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Am J Physiol Regul Integr Comp Physiol 279: R1310-R1315, 2000;
0363-6119/00 $5.00
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Vol. 279, Issue 4, R1310-R1315, October 2000

Conditioned suppression of contact sensitivity is independent of sympathetic splenic innervation

Michael S. Exton1, Alexandra Elfers1, Woo-Young Jeong1, Diane F. Bull2, Jürgen Westermann3, and Manfred Schedlowski1

1 Institute for Medical Psychology, Faculty of Medicine, University of Essen, 45122 Essen, 3 Division of Functional and Applied Anatomy, Hannover Medical School, 30623 Hannover, Germany; and 2 Department of Psychology, University of Newcastle, Ourimbah, Australia 2258

The present study investigated the role of sympathetic innervation of the spleen in conditioned suppression of a contact hypersensitivity (CHS) reaction. Behavioral conditioning was achieved by pairing saccharin drinking solution (conditioned stimulus, CS) with injection of cyclosporin A (CsA, 20 mg/kg; unconditioned stimulus, UCS). Four days after sensitization of the animals by application of a 5% 2,4-dinitrochlorobenzene (DNCB) to abdominal skin, the animals were challenged by applying a 1% DNCB solution to the ear. The CHS response was monitored by measuring the degree of ear swelling. Saccharin re-presentation reduced ear swelling to a magnitude that approached that achieved by CsA treatment. Histological examination demonstrated that the conditioned reduction of ear swelling was produced by a reduced leukocyte infiltration of the ear. Prior sympathetic denervation of the spleen did not alter the conditioned suppression of the CHS response. These data indicate that behavioral conditioning using CsA produces alterations of CHS that, unlike conditioned prolongation of heart allograft survival, are independent of sympathetically regulated conditioned alterations in the spleen.

classical conditioning; cyclosporin


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