AJP - Regu Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 279: R1403-R1411, 2000;
0363-6119/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (12)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Brot, M. D.
Right arrow Articles by Bernstein, I. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brot, M. D.
Right arrow Articles by Bernstein, I. L.
Vol. 279, Issue 4, R1403-R1411, October 2000

Amiloride-sensitive signals and NaCl preference and appetite: a lick-rate analysis

Michelle D. Brot1, Chae H. Watson2, and Ilene L. Bernstein2

Departments of 1 Orthodontics and 2 Psychology, University of Washington, Seattle, Washington 98195

Rats prefer hypotonic and isotonic NaCl solutions to water in long-access drinking paradigms. To focus on the role of taste signals in NaCl preference, licking patterns of rats with 30-s exposure to NaCl solutions (0-0.5 M) were examined when they were either water deprived, sodium depleted, or not deprived (NaCl mixed in dilute sucrose). In all three conditions, rats displayed a preference for NaCl. The addition of 100 µM amiloride, a sodium channel blocker, to NaCl did not change rats' licking when they were sodium replete but dramatically reduced licking when they were deplete. Transection of the chorda tympani (CT) nerve, an afferent pathway for amiloride-sensitive Na+ signals, had no effect on NaCl preference in nondeprived rats and only a modest effect on those that were Na+ deplete. Amiloride was found to exert significant suppression of NaCl intake in Na+-depleted rats with transection of the CT, supporting the existence of other afferent pathways for transmission of amiloride-sensitive Na+ signalling. Together, these studies argue for the involvement of different neural signalling mechanisms in NaCl preference in the presence and absence of explicit Na+ need.

lickometer; drinking; rats; taste; chorda tympani


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. M. Garcia, K. S. Curtis, and R. J. Contreras
Behavioral and electrophysiological taste responses change after brief or prolonged dietary sodium deprivation
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2008; 295(6): R1754 - R1761.
[Abstract] [Full Text] [PDF]

Home page
 Chem SensesHome page
S. D. Hillyard, V. Baula, W. Tuttle, N. J. Willumsen, and E. H. Larsen
Behavioral and Neural Responses of Toads to Salt Solutions Correlate with Basolateral Membrane Potential of Epidermal Cells of the Skin
Chem Senses, October 1, 2007; 32(8): 765 - 773.
[Abstract] [Full Text] [PDF]

Home page
 Chem SensesHome page
D. M. Dietz, K. S. Curtis, and R. J. Contreras
Taste, Salience, and Increased NaCl Ingestion after Repeated Sodium Depletions
Chem Senses, January 1, 2006; 31(1): 33 - 41.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. Eylam and A. C. Spector
Taste discrimination between NaCl and KCl is disrupted by amiloride in inbred mice with amiloride-insensitive chorda tympani nerves
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2005; 288(5): R1361 - R1368.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
K. S. Curtis, E. G. Krause, D. L. Wong, and R. J. Contreras
Gestational and early postnatal dietary NaCl levels affect NaCl intake, but not stimulated water intake, by adult rats
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2004; 286(6): R1043 - R1050.
[Abstract] [Full Text] [PDF]

Home page
 Chem SensesHome page
S. Eylam and A. C. Spector
Oral Amiloride Treatment Decreases Taste Sensitivity to Sodium Salts in C57BL/6J and DBA/2J Mice
Chem Senses, June 1, 2003; 28(5): 447 - 458.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online