AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 279: R1455-R1466, 2000;
0363-6119/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (13)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wideman, L.
Right arrow Articles by Veldhuis, J. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wideman, L.
Right arrow Articles by Veldhuis, J. D.
Vol. 279, Issue 4, R1455-R1466, October 2000

Synergy of L-arginine and growth hormone (GH)-releasing peptide-2 on GH release: influence of gender

Laurie Wideman1,2, Judy Y. Weltman1,2, James T. Patrie3, C. Y. Bowers4, Niki Shah1, Shannon Story1, Arthur Weltman1,2,5, and Johannes D. Veldhuis1,2,6

Departments of 1 Internal Medicine, 3 Health Evaluation Sciences, and 5 Human Services, 2 General Clinical Research Center, and 6 National Science Foundation Center for Biological Timing, University of Virginia, Charlottesville, Virginia 22908; and 4 Division of Endocrinology and Metabolism, Tulane University, New Orleans, Louisiana 70112

We test the hypotheses that 1) growth hormone (GH)-releasing peptide-2 (G) synergizes with L-arginine (A), a compound putatively achieving selective somatostatin withdrawal and 2) gender modulates this synergy on GH secretion. To these ends, 18 young healthy volunteers (9 men and 9 early follicular phase women) each received separate morning intravenous infusions of saline (S) or A (30 g over 30 min) or G (1 µg/kg) or both, in randomly assigned order. Blood was sampled at 10-min intervals for later chemiluminescence assay of serum GH concentrations. Analysis of covariance revealed that the preinjection (basal) serum GH concentrations significantly determined secretagogue responsiveness and that sex (P = 0.02) and stimulus type (P < 0.001) determined the slope of this relationship. Nested ANOVA applied to log-transformed measures of GH release showed that gender determines 1) basal rates of GH secretion, 2) the magnitude of the GH secretory response to A, 3) the rapidity of attaining the GH maximum, and 4) the magnitude or fold (but not absolute) elevation in GH secretion above preinjection basal, as driven by the combination of A and G. In contrast, the emergence of the G and A synergy is sex independent. We conclude that gender modulates key facets of basal and A/G-stimulated GH secretion in young adults.

male; female; pituitary; somatotropin; regulation; endocrine


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
L. S. Farhy, C. Y. Bowers, and J. D. Veldhuis
Model-projected mechanistic bases for sex differences in growth hormone regulation in humans
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2007; 292(4): R1577 - R1593.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L. Wideman, L. Consitt, J. Patrie, B. Swearingin, R. Bloomer, P. Davis, and A. Weltman
The impact of sex and exercise duration on growth hormone secretion
J Appl Physiol, December 1, 2006; 101(6): 1641 - 1647.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
R. Nass, S. S. Pezzoli, I. M. Chapman, J. Patrie, R. L. Hintz, M. L. Hartman, and M. O. Thorner
IGF-I does not affect the net increase in GH release in response to arginine
Am J Physiol Endocrinol Metab, October 1, 2002; 283(4): E702 - E710.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
L. Wideman, J. Y. Weltman, J. T. Patrie, C. Y. Bowers, N. Shah, S. Story, J. D. Veldhuis, and A. Weltman
Synergy of L-arginine and GHRP-2 stimulation of growth hormone in men and women: modulation by exercise
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2000; 279(4): R1467 - R1477.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. J. Pritzlaff-Roy, L. Widemen, J. Y. Weltman, R. Abbott, M. Gutgesell, M. L. Hartman, J. D. Veldhuis, and A. Weltman
Gender governs the relationship between exercise intensity and growth hormone release in young adults
J Appl Physiol, May 1, 2002; 92(5): 2053 - 2060.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online