AJP - Regu Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 279: R1467-R1477, 2000;
0363-6119/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (17)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wideman, L.
Right arrow Articles by Weltman, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wideman, L.
Right arrow Articles by Weltman, A.
Vol. 279, Issue 4, R1467-R1477, October 2000

Synergy of L-arginine and GHRP-2 stimulation of growth hormone in men and women: modulation by exercise

Laurie Wideman1,2, Judy Y. Weltman1,2, James T. Patrie3, Cyril Y. Bowers4, Niki Shah1, Shannon Story1, Johannes D. Veldhuis1,2,5, and Arthur Weltman1,2,6

Departments of 1 Internal Medicine, 3 Health Evaluation Sciences, and 6 Human Services, 2 General Clinical Research Center, and 5 National Science Foundation Center for Biological Timing, University of Virginia, Charlottesville, Virginia 22903; and 4 Division of Endocrinology and Metabolism, Tulane University, New Orleans, Louisiana 70112

We investigated the ability of exercise, a multipathway, potent, physiological stimulus for GH release, to alter the synergistic interaction of L-arginine (A) and GH-related peptide (GHRP)-2 (G) observed at rest and the ability of gender to further modulate this putative interaction. Subjects (9 men and 9 early follicular phase women) completed 30 min of constant load aerobic exercise in combination with intravenous infusions of saline (S), A (30 g over 30 min), G (1 µg/kg bolus), or both (AG) in separate study sessions in randomly assigned order. Measures of GH release were logarithmically transformed for statistical analysis. Similar to rest, exercise maintained the rank order (AG > G > A > S) of effective stimulation of GH release for the key response measures in men or women, a gender disparity in the time to reach the maximal serum GH concentration, the calculated endogenous GH half-life, and the observed effect of preinfusion (basal) serum GH concentrations on determining secretagogue responsiveness. Exercise potentiated the individual stimulatory actions of A and G, while blunting the relative magnitude of the synergistic (supra-additive) interaction observed at rest. We infer from the present data that 1) exercise is likely to induce release of both GHRH and somatostatin, 2) L-arginine may facilitate the effect of exercise by limiting somatostatin release, 3) GHRP-2 could further enhance the stimulatory impact of exercise by opposing central actions of somatostatin and/or heightening endogenous GHRH release, and 4) gender strongly controls the relative but not absolute magnitude of A/G synergy both at rest and after exercise.

male; female; pituitary; somatotropin; regulation; endocrine


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
L. Wideman, L. Consitt, J. Patrie, B. Swearingin, R. Bloomer, P. Davis, and A. Weltman
The impact of sex and exercise duration on growth hormone secretion
J Appl Physiol, December 1, 2006; 101(6): 1641 - 1647.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. R. Collier, E. Collins, and J. A. Kanaley
Oral arginine attenuates the growth hormone response to resistance exercise
J Appl Physiol, September 1, 2006; 101(3): 848 - 852.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. Weltman, J. Y. Weltman, C. P. Roy, L. Wideman, J. Patrie, W. S. Evans, and J. D. Veldhuis
Growth hormone response to graded exercise intensities is attenuated and the gender difference abolished in older adults
J Appl Physiol, May 1, 2006; 100(5): 1623 - 1629.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
L. Wideman, J. Y. Weltman, J. T. Patrie, C. Y. Bowers, N. Shah, S. Story, A. Weltman, and J. D. Veldhuis
Synergy of L-arginine and growth hormone (GH)-releasing peptide-2 on GH release: influence of gender
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2000; 279(4): R1455 - R1466.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online