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-Estradiol prevents oxidative stress and decreases blood
pressure in ovariectomized rats
Universidad de Murcia, Facultad de Medicina, Departamento de Fisiología y Farmacología, 30100 Murcia, Spain
In this study, we tested whether
estrogen deficiency is associated with oxidative stress and decreased
nitric oxide (NO) production, which could be responsible for an
increased blood pressure in ovariectomized rats. Hemodynamic studies
were performed on conscious, chronically instrumented rats. Chronic
estrogen replacement on ovariectomized rats lowered blood pressure
~13 mmHg, from 119 ± 3 mmHg in ovariectomized rats to 106 ± 3 mmHg in ovariectomized-treated rats; it was also accompanied by an increase in cardiac index and vascular conductance, achieving hemodynamic values similar to those shown by sham-operated rats. NG-nitro-L-arginine methyl ester
administration lowered significantly less the vascular conductance
(0.14 ± 0.01 vs. 0.22 ± 0.03 and 0.26 ± 0.01 ml · min
1 · mmHg1/100 g;
P < 0.05) in ovariectomized rats than in the
sham-operated and estrogen-treated ovariectomized rats, respectively.
Estrogen replacement prevented the lower plasma levels of
nitrites/nitrates observed in ovariectomized rats. The lower plasma
total antioxidant status and reduced thiol groups and the increase in
plasma lipoperoxides presented in ovariectomized animals were
reestablished with the estrogen treatment. These results show that
estrogen administration decreases blood pressure and increases vascular
conductance in ovariectomized rats. This effect may be related to an
increase in NO synthesis and/or preventing oxidative stress, then
improving endothelial function.
cardiac output; vascular conductance; nitric oxide
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