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Am J Physiol Regul Integr Comp Physiol 279: R2149-R2155, 2000;
0363-6119/00 $5.00
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Vol. 279, Issue 6, R2149-R2155, December 2000

Improved cardiac performance after ischemia in aged rats supplemented with vitamin E and alpha -lipoic acid

Jeff S. Coombes1, Scott K. Powers1, Karyn L. Hamilton1, Haydar A. Demirel1, R. Andrew Shanely1, Murat A. Zergeroglu1, Chandan K. Sen2,3, Lester Packer2, and Li Li Ji4

1 Center for Exercise Science, University of Florida, Gainesville, Florida 32611; 2 Department of Molecular and Cell Biology, University of California, Berkeley, California 94720; 3 Department of Physiology, University of Kuopio, Kuopio, Finland 70211; and 4 Department of Kinesiology, University of Wisconsin, Madison, Wisconsin 53706

The purpose of these experiments was to examine the effects of dietary antioxidant supplementation with vitamin E (VE) and alpha -lipoic acid (alpha -LA) on biochemical and physiological responses to in vivo myocardial ischemia-reperfusion (I-R) in aged rats. Male Fischer-334 rats (18 mo old) were assigned to either 1) a control diet (CON) or 2) a VE and alpha -LA supplemented diet (ANTIOX). After a 14-wk feeding period, animals in each group underwent an in vivo I-R protocol (25 min of myocardial ischemia and 15 min of reperfusion). During reperfusion, peak arterial pressure was significantly higher (P < 0.05) in ANTIOX animals compared with CON diet animals. I-R resulted in a significant increase (P < 0.05) in myocardial lipid peroxidation in CON diet animals but not in ANTIOX animals. Compared with ANTIOX animals, heart homogenates from CON animals experienced significantly less (P < 0.05) oxidative damage when exposed to five different in vitro radical producing systems. These data indicate that dietary supplementation with VE and alpha -LA protects the aged rat heart from I-R-induced lipid peroxidation by scavenging numerous reactive oxygen species. Importantly, this protection is associated with improved cardiac performance during reperfusion.

aging; free radicals; lipid peroxidation; myocardial performance


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