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Am J Physiol Regul Integr Comp Physiol 279: R2164-R2172, 2000;
0363-6119/00 $5.00
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Vol. 279, Issue 6, R2164-R2172, December 2000

Bacterial translocation can increase plasma corticosterone and brain catecholamine and indoleamine metabolism

Tetsuya Ando1, Rhonda F. Brown1, Rodney D. Berg2, and Adrian J. Dunn1

Departments of 1 Pharmacology and Therapeutics and 2 Microbiology and Immunology, Louisiana State University Medical Center, Shreveport, Louisiana 71130

The potential contribution of stress-induced bacterial translocation to the activation of the hypothalamo-pituitary-adrenocortical (HPA) axis and brain biogenic amines was assessed. Mice were restrained for various periods, and brain concentrations of tryptophan, catecholamines, serotonin, and their metabolites, plasma corticosterone, and the translocation of viable bacteria from the gastrointestinal tract to the mesenteric lymph nodes, spleen, and liver were measured. Restraint induced the translocation of indigenous gram-positive bacteria in only a small proportion of animals, but translocation of gram-negative bacteria did not occur. Restraint induced short-lived increases in plasma corticosterone and brain amine metabolism, whereas bacterial translocation was slower and persisted long after the HPA axis and neurochemical responses had dissipated. When mice were infected with Salmonella typhimurium, spontaneous translocation occurred and plasma corticosterone, interleukin-6 concentrations, and brain catecholamine and indoleamine metabolism were elevated. These findings indicate that the translocation of indigenous gastrointestinal bacteria did not contribute to the HPA axis and neurochemical changes induced by restraint. However, translocation of nonindigenous S. typhimurium with or without restraint did induce HPA and neurochemical responses.

Salmonella typhimurium; tryptophan; catecholamines; serotonin; corticosterone


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