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1 Zoological Institute, University of Innsbruck, A-6020 Innsbruck, Austria; and 2 Department of Zoophysiology, University of Göteborg, 405 30 Göteborg, Sweden
We used a newly developed digital
motion analysis video technique to study the effects of nitric oxide
(NO) and epinephrine on the early larval arterial and venous
vasculature of zebrafish. Application of the NO donor sodium
nitroprusside resulted in a significant increase in both the venous and
arterial vessel diameters, whereas
NG-nitro-L-arginine methyl ester
caused a significant decrease in the same diameters. Thus our results
show that both the venous and arterial vasculature of the 5- and
6-day-old zebrafish larvae are influenced by endogenously produced NO.
By use of immunohistochemistry, NO synthase immunoreactivity was
demonstrated in endothelial cells of the dorsal vein. Local application
of epinephrine onto the dorsal artery had no effect on vessel diameter.
However, if the embryos were preincubated with
N
-nitro-L-arginine methyl
ester, addition of epinephrine resulted in a significant
reduction in both arterial and venous vessel diameters. Thus this study
provides increasing evidence that before a functional autonomic
innervation of the peripheral vascular system, vascular tone in larval
tissue is regulated by a complex interaction of vasoactive substances
that are produced locally by vascular endothelial cells.
ontogeny; nitric oxide synthase; epinephrine; cardiac; immunohistochemistry
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