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Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260
The present study
sought to determine whether increases in arterial blood pressure
inhibited drinking behavior evoked by ANG II, hyperosmolality, or
hypovolemia in rats. Cumulative water intakes in 60- or 90-min tests
and latency to the first lick were recorded as indexes of thirst.
During intravenous infusions of 100 ng · kg
1 · min1 ANG II,
attenuation of the induced increases in arterial pressure with the
arteriolar vasodilator diazoxide resulted in greater water intakes and
shorter latencies to drink. Drinking behavior stimulated by intravenous
infusion of hypertonic saline was significantly inhibited by increases
in arterial pressure caused by intravenous infusion of phenylephrine or
endothelin-1, and this inhibition of drinking was proportional to the
induced increase in pressure. Upon termination of the phenylephrine
infusion, mean arterial pressure returned to basal values, and drinking
was restored. Phenylephrine-induced increases in arterial pressure also
inhibited drinking behavior in response to hypovolemia that could not
be explained by differences in plasma renin activity, plasma protein concentration, or plasma osmolality. Thus increases in arterial pressure inhibit water drinking behavior in response to each of these
three thirst stimuli in rats.
water intake; blood pressure; baroreceptors
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