AJP - Regu Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 280: R62-R68, 2001;
0363-6119/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (38)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Leonard, B. L.
Right arrow Articles by Evans, R. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Leonard, B. L.
Right arrow Articles by Evans, R. G.
Vol. 280, Issue 1, R62-R68, January 2001

Differential control of intrarenal blood flow during reflex increases in sympathetic nerve activity

Bridget L. Leonard1, Simon C. Malpas1, Kate M. Denton2, Anna C. Madden2, and Roger G. Evans2

1 Circulatory Control Laboratory, Department of Physiology, University of Auckland, Auckland, New Zealand; and 2 Department of Physiology, Monash University, Melbourne, Victoria 3168, Australia

The role of renal sympathetic nerve activity (RSNA) in the physiological regulation of medullary blood flow (MBF) remains ill defined, yet regulation of MBF may be crucial to long-term arterial pressure regulation. To investigate the effects of reflex increases in RSNA on intrarenal blood flow distribution, we exposed pentobarbital sodium-anesthetized, artificially ventilated rabbits (n = 7) to progressive hypoxia while recording RSNA, cortical blood flow (CBF), and MBF using laser-Doppler flowmetry. Another group of animals with denervated kidneys (n = 6) underwent the same protocol. Progressive hypoxia (from room air to 16, 14, 12, and 10% inspired O2) significantly reduced arterial oxygen partial pressure (from 99 ± 3 to 65 ± 2, 51 ± 2, 41 ± 1, and 39 ± 2 mmHg, respectively) and significantly increased RSNA (by 8 ± 3, 44 ± 25, 62 ± 21, and 76 ± 37%, respectively, compared with room air) without affecting mean arterial pressure. There were significant reductions in CBF (by 2 ± 1, 5 ± 2, 11 ± 3, and 14 ± 2%, respectively) in intact but not denervated rabbits. MBF was unaffected by hypoxia in either group. Thus moderate reflex increases in RSNA cause renal cortical vasoconstriction, but not at vascular sites regulating MBF.

cortical blood flow; hypoxia; medullary blood flow; renal sympathetic nerve activity; anesthetized rabbit


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. Michaels, G. A. Eppel, S. L. Burke, G. A. Head, J. Armitage, J. F. Carroll, S. C. Malpas, and R. G. Evans
Altered responsiveness of the kidney to activation of the renal nerves in fat-fed rabbits
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2009; 296(6): R1889 - R1896.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
R. G. Evans, B. S. Gardiner, D. W. Smith, and P. M. O'Connor
Intrarenal oxygenation: unique challenges and the biophysical basis of homeostasis
Am J Physiol Renal Physiol, November 1, 2008; 295(5): F1259 - F1270.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
T. Ditting, K. F. Hilgers, A. Stetter, P. Linz, C. Schonweiss, and R. Veelken
Renal sympathetic nerves modulate erythropoietin plasma levels after transient hemorrhage in rats
Am J Physiol Renal Physiol, October 1, 2007; 293(4): F1099 - F1106.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
R. G. Evans, S. L. Burke, G. W. Lambert, and G. A. Head
Renal responses to acute reflex activation of renal sympathetic nerve activity and renal denervation in secondary hypertension
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1247 - R1256.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
C.-L. Leong, W. P. Anderson, P. M. O'Connor, and R. G. Evans
Evidence that renal arterial-venous oxygen shunting contributes to dynamic regulation of renal oxygenation
Am J Physiol Renal Physiol, June 1, 2007; 292(6): F1726 - F1733.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
S. L. Burke, G. A. Head, G. W. Lambert, and R. G. Evans
Renal Sympathetic Neuroeffector Function in Renovascular and Angiotensin II-Dependent Hypertension in Rabbits
Hypertension, April 1, 2007; 49(4): 932 - 938.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
P. M. O'Connor, M. M. Kett, W. P. Anderson, and R. G. Evans
Renal medullary tissue oxygenation is dependent on both cortical and medullary blood flow
Am J Physiol Renal Physiol, March 1, 2006; 290(3): F688 - F694.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
N. W. Rajapakse, A. K. Sampson, G. A. Eppel, and R. G. Evans
Angiotensin II and nitric oxide in neural control of intrarenal blood flow
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2005; 289(3): R745 - R754.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
K. M. Denton, A. Shweta, R. L. Flower, and W. P. Anderson
Predominant postglomerular vascular resistance response to reflex renal sympathetic nerve activation during ANG II clamp in rabbits
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2004; 287(4): R780 - R786.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. Momen, U. A. Leuenberger, C. A. Ray, S. Cha, B. Handly, and L. I. Sinoway
Renal vascular responses to static handgrip: role of muscle mechanoreflex
Am J Physiol Heart Circ Physiol, August 7, 2003; 285(3): H1247 - H1253.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
L. M. Duke, G. A. Eppel, R. E. Widdop, and R. G. Evans
Disparate Roles of AT2 Receptors in the Renal Cortical and Medullary Circulations of Anesthetized Rabbits
Hypertension, August 1, 2003; 42(2): 200 - 205.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. B. Persson
The kidney and hypertension
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2003; 284(5): R1176 - R1178.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
S. Malpas, S.-J. Guild, R. Evans, and G. F. DiBona
Responsiveness of the Renal Vasculature: Relating Electrical Stimulation to Endogenous Nerve Activity Is Problematic
Am J Physiol Renal Physiol, March 1, 2003; 284(3): F594 - F596.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
G. A. Eppel, G. Bergstrom, W. P. Anderson, and R. G. Evans
Autoregulation of renal medullary blood flow in rabbits
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2003; 284(1): R233 - R244.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. B. Persson
Nitric oxide in the kidney
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2002; 283(5): R1005 - R1007.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S.-J. Guild, G. A. Eppel, S. C. Malpas, N. W. Rajapakse, A. Stewart, and R. G. Evans
Regional responsiveness of renal perfusion to activation of the renal nerves
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2002; 283(5): R1177 - R1186.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
O. Grisk and H. M. Stauss
Frequency modulation of mesenteric and renal vascular resistance
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2002; 282(5): R1468 - R1476.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
K. M. Denton, A. Shweta, and W. P. Anderson
Preglomerular and Postglomerular Resistance Responses to Different Levels of Sympathetic Activation by Hypoxia
J. Am. Soc. Nephrol., January 1, 2002; 13(1): 27 - 34.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. F. Morrison
Differential control of sympathetic outflow
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2001; 281(3): R683 - R698.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
B. J. A. Janssen, E. V. Lukoshkova, and G. A. Head
Sympathetic modulation of renal blood flow by rilmenidine and captopril: central vs. peripheral effects
Am J Physiol Renal Physiol, January 1, 2002; 282(1): F113 - F123.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online