AJP - Regu Watch the video to see how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 280: R323-R330, 2001;
0363-6119/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (25)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chopard, A.
Right arrow Articles by Marini, J.-F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chopard, A.
Right arrow Articles by Marini, J.-F.
Vol. 280, Issue 2, R323-R330, February 2001

Cytoskeletal protein contents before and after hindlimb suspension in a fast and slow rat skeletal muscle

Angele Chopard1,2, Françoise Pons3, and Jean-François Marini1,2

1 Laboratoire de Physiologie Cellulaire et Moléculaire des Systèmes Intégrés, Centre National de la Recherche Scientifique Unité Mixte de Recherche 6548, Faculté des Sciences, 06108 Nice Cedex 2; 2 Laboratoire Structure et Fonction du Muscle, Faculté des Sciences du Sport, 06205 Nice Cedex 3; and 3 Laboratoire de Biochimie des Membranes, Faculté de Pharmacie, 34060 Montpellier Cedex, France

Transversal cytoskeletal organization of muscle fibers is well described, although very few data are available concerning protein content. Measurements of desmin, alpha -actinin, and actin contents in soleus and extensor digitorum longus (EDL) rat skeletal muscles, taken with the results previously reported for several dystrophin-glycoprotein complex (DGC) components, indicate that the contents of most cytoskeletal proteins are higher in slow-type fibers than in fast ones. The effects of hypokinesia and unloading on the cytoskeleton were also investigated, using hindlimb suspension. First, this resulted in a decrease in contractile protein contents, only after 6 wk, in the soleus. Dystrophin and associated proteins were shown to be reduced for soleus at 3 wk, whereas only the dystrophin-associated proteins were found to increase after 6 wk. On the other hand, the contents of DGC components were increased for EDL for the two durations. Desmin and alpha -actinin levels were unchanged in the same conditions. Consequently, it can be concluded that the cytoskeletal protein expression levels could largely contribute to muscle fiber adaptation induced by modified functional demands.

cytoskeleton; fast and slow muscle fibers; quantitative analysis; atrophy


This article has been cited by other articles:


Home page
 Physiol. GenomicsHome page
A. Chopard, M. Lecunff, R. Danger, G. Lamirault, A. Bihouee, R. Teusan, B. J. Jasmin, J. F. Marini, and J. J. Leger
Large-scale mRNA analysis of female skeletal muscles during 60 days of bed rest with and without exercise or dietary protein supplementation as countermeasures
Physiol Genomics, August 7, 2009; 38(3): 291 - 302.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. J. Widrick, G. F. Maddalozzo, H. Hu, J. C. Herron, U. T. Iwaniec, and R. T. Turner
Detrimental effects of reloading recovery on force, shortening velocity, and power of soleus muscles from hindlimb-unloaded rats
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2008; 295(5): R1585 - R1592.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. Mac Gabhann, J. W. Ji, and A. S. Popel
VEGF gradients, receptor activation, and sprout guidance in resting and exercising skeletal muscle
J Appl Physiol, February 1, 2007; 102(2): 722 - 734.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
K. M. Rice, D. L. Preston, D. Neff, M. Norton, and E. R. Blough
Age-Related Dystrophin-Glycoprotein Complex Structure and Function in the Rat Extensor Digitorum Longus and Soleus Muscle
J. Gerontol. A Biol. Sci. Med. Sci., November 1, 2006; 61(11): 1119 - 1129.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. T. Woolstenhulme, R. K. Conlee, M. J. Drummond, A. W. Stites, and A. C. Parcell
Temporal response of desmin and dystrophin proteins to progressive resistance exercise in human skeletal muscle
J Appl Physiol, June 1, 2006; 100(6): 1876 - 1882.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. M. McClung, R. W. Thompson, L. L. Lowe, and J. A. Carson
RhoA expression during recovery from skeletal muscle disuse
J Appl Physiol, April 1, 2004; 96(4): 1341 - 1348.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
R. M. Lovering and P. G. De Deyne
Contractile function, sarcolemma integrity, and the loss of dystrophin after skeletal muscle eccentric contraction-induced injury
Am J Physiol Cell Physiol, February 1, 2004; 286(2): C230 - C238.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. Fluck, M. Chiquet, S. Schmutz, M.-H. Mayet-Sornay, and D. Desplanches
Reloading of atrophied rat soleus muscle induces tenascin-C expression around damaged muscle fibers
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2003; 284(3): R792 - R801.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. Schnermann
Exercise
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2002; 283(1): R2 - R6.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online