AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 280: R345-R354, 2001;
0363-6119/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (7)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Taylor, B. K.
Right arrow Articles by Basbaum, A. I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Taylor, B. K.
Right arrow Articles by Basbaum, A. I.
Vol. 280, Issue 2, R345-R354, February 2001

Hypoalgesia and hyperalgesia with inherited hypertension in the rat

Bradley K. Taylor1, Robyn E. Roderick2, Elizabeth St. Lezin3, and Allan I. Basbaum2

1 Division of Pharmacology, School of Pharmacy, University of Missouri-Kansas City, Kansas City, Missouri 64108; 2 W. M. Keck Foundation Center for Integrative Neuroscience and Departments of Anatomy and Physiology and 3 Laboratory Medicine, University of California San Francisco, San Francisco, California 94143

Many studies indicate that blood pressure control systems can attenuate pain (hypoalgesia) of short duration; however, we recently found exaggerated nociceptive responses (hyperalgesia) of persistent duration in the spontaneously hypertensive rat (SHR). Here, we used SHR, Dahl Salt-Sensitive (SS), and normotensive control rats to evaluate the contribution of sustained elevations in arterial pressure to nociceptive responses. Compared with Sprague-Dawley and/or Wistar-Kyoto controls, SHR were 1) hypoalgesic in the hot plate test and 2) hyperalgesic in longer latency tail and paw-withdrawal tests and in two models of inflammatory nociception. These differences were not observed between SS and salt-resistant controls fed a high-salt diet. Inflammatory hyperalgesia in SHR was correlated with neither paw edema nor the number of Fos-positive spinal cord neurons. Our results indicate that "pain" phenotype of the SHR is not restricted to hypoalgesia. This phenotype is related to genetic factors or to the autonomic systems that control blood pressure and not to sustained elevations in blood pressure, differences in spinal neuron activity, or inflammatory edema.

pain; inflammation; Dahl salt-sensitive rat; spontaneously hypertensive rat


This article has been cited by other articles:


Home page
 Schizophr BullHome page
M. B. Calzavara, W. A. Medrano, R. Levin, S. R. Kameda, M. L. Andersen, S. Tufik, R. H. Silva, R. Frussa-Filho, and V. C. Abilio
Neuroleptic Drugs Revert the Contextual Fear Conditioning Deficit Presented by Spontaneously Hypertensive Rats: A Potential Animal Model of Emotional Context Processing in Schizophrenia?
Schizophr Bull, February 16, 2008; (2008) sbn006v1.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
T. B. Mahinda, B. M. Lovell, and B. K. Taylor
Morphine-Induced Analgesia, Hypotension, and Bradycardia Are Enhanced in Hypertensive Rats
Anesth. Analg., June 1, 2004; 98(6): 1698 - 1704.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online