| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Max Delbrück Center for Molecular Medicine, D-13092 Berlin-Buch, Germany; and 2 Federal University of Minas Gerais, 31 270-901 Belo Horizonte, Brazil
The transgenic rats TGR(ASrAOGEN) (TGR) with low levels of brain angiotensinogen were analyzed for cardiovascular reactivity to microinjections of ANG II and angiotensin receptor (AT1) antagonists [CV-11974, AT1 specific; A-779, ANG-(1-7) selective; sarthran, nonspecific] into the rostral ventrolateral medulla (RVLM) of conscious rats. Microinjection of ANG II resulted in a significantly higher increase in the mean arterial pressure (MAP) of TGR than control [Sprague-Dawley (SD)] rats, suggesting an upregulation of ANG II receptors in TGR. CV-11974 produced an increase in MAP of SD but not in TGR rats. A-779 produced a depressor response in SD but not in TGR rats. Conversely, sarthran produced a similar decrease of MAP in both rat groups. The pressor effect of the AT1 antagonist may indicate an inhibitory role of AT1 receptors in the RVLM. On the other hand, ANG-(1-7) appears to have a tonic excitatory role in this region. The altered response to specific angiotensin antagonists in TGR further supports the functionally relevant decrease in angiotensins in the brains of TGR and corroborates the importance of the central renin-angiotensin system in cardiovascular homeostasis.
brain renin-angiotensin system; rostral ventrolateral medulla; blood pressure
This article has been cited by other articles:
|
|
 |
|
  A. Sakima, D. B. Averill, S. O. Kasper, L. Jackson, D. Ganten, C. M. Ferrario, P. E. Gallagher, and D. I. Diz Baroreceptor reflex regulation in anesthetized transgenic rats with low glia-derived angiotensinogen Am J Physiol Heart Circ Physiol, March 1, 2007; 292(3): H1412 - H1419. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Campos, R. Iliescu, M. A. P. Fontes, W.-P. Schlegel, M. Bader, and O. C. Baltatu Enhanced isoproterenol-induced cardiac hypertrophy in transgenic rats with low brain angiotensinogen Am J Physiol Heart Circ Physiol, November 1, 2006; 291(5): H2371 - H2376. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. C. Alzamora, R. A. S. Santos, and M. J. Campagnole-Santos Baroreflex modulation by angiotensins at the rat rostral and caudal ventrolateral medulla Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2006; 290(4): R1027 - R1034. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Campos, R. Plehm, J. Cipolla-Neto, M. Bader, and O. C. Baltatu Altered circadian rhythm reentrainment to light phase shifts in rats with low levels of brain angiotensinogen Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2006; 290(4): R1122 - R1127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Davisson Physiological genomic analysis of the brain renin-angiotensin system Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2003; 285(3): R498 - R511. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Skott Renin Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2002; 282(4): R937 - R939. [Full Text] [PDF]
|
|
|
|
 |
|
 S. Morimoto, M. D. Cassell, T. G. Beltz, A. K. Johnson, R. L. Davisson, and C. D. Sigmund Elevated Blood Pressure in Transgenic Mice With Brain-Specific Expression of Human Angiotensinogen Driven by the Glial Fibrillary Acidic Protein Promoter Circ. Res., August 17, 2001; 89(4): 365 - 372. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
