| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Veterans Affairs Medical Center and 3 Minnesota Obesity Center, Minneapolis 55417, and 4 Departments of Food Science and Nutrition, 5 Psychiatry, and 2 Medicine, University of Minnesota, Saint Paul, Minnesota 55108
Ventricular administration of urocortin (UCN) inhibits feeding, but specific site(s) of UCN action are unknown. In the current studies we examined the effect of UCN in the hypothalamic paraventricular nucleus (PVN) on feeding. We tested UCN administered into the PVN in several paradigms: deprivation-induced, nocturnal, and neuropeptide Y (NPY)-induced feeding. We compared the effect of equimolar doses of UCN and corticotrophin releasing hormone (CRH) on NPY-induced and nocturnal feeding, determined whether UCN in the PVN produced a conditioned taste aversion (CTA) and induced changes in c-Fos immunoreactivity (c-Fos-ir) after UCN and NPY administration in the PVN. UCN in the PVN significantly decreased NPY and nocturnal and deprivation-induced feeding at doses of 1, 10, and 100 pmol, respectively. UCN anorectic effects lasted longer than those attributed to CRH. Ten and thirty picomoles UCN did not induce a CTA, whereas 100 pmol UCN produced a CTA. UCN (100 pmol) in the PVN neither increased c-Fos-ir in any brain region assayed nor altered c-Fos-ir patterns resulting from PVN NPY administration. These data suggest the hypothalamic PVN as a site of UCN action.
energy balance; neuropeptide Y; feeding behavior; brain sites
This article has been cited by other articles:
|
|
 |
|
  V. P. Bakshi, S. M. Newman, S. Smith-Roe, K. A. Jochman, and N. H. Kalin Stimulation of Lateral Septum CRF2 Receptors Promotes Anorexia and Stress-Like Behaviors: Functional Homology to CRF1 Receptors in Basolateral Amygdala J. Neurosci., September 26, 2007; 27(39): 10568 - 10577. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Wang, E. Bomberg, C. Billington, A. Levine, and C. M. Kotz Brain-derived neurotrophic factor in the hypothalamic paraventricular nucleus reduces energy intake Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1003 - R1012. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. J. Bernier and P. M. Craig CRF-related peptides contribute to stress response and regulation of appetite in hypoxic rainbow trout Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2005; 289(4): R982 - R990. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. A. Cupples Peptides that regulate food intake Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2003; 284(6): R1370 - R1374. [Full Text] [PDF]
|
|
|
|
|
|
W. A. Cupples Regulating food intake Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2003; 284(3): R652 - R654. [Full Text] [PDF]
|
|
|
|
|
|
W. A. Cupples Integrating the regulation of food intake Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2002; 283(2): R356 - R357. [Full Text] [PDF]
|
|
|
|
|
|
C. Wang and C. M. Kotz Urocortin in the lateral septal area modulates feeding induced by orexin A in the lateral hypothalamus Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2002; 283(2): R358 - R367. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Ahima, H. R. Patel, N. Takahashi, Y. Qi, S. M. Hileman, and M. A. Zasloff Appetite Suppression and Weight Reduction by a Centrally Active Aminosterol Diabetes, July 1, 2002; 51(7): 2099 - 2104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. F. DiBona Neuropeptide Y Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2002; 282(3): R635 - R636. [Full Text] [PDF]
|
|
|
|
|
|
C. M. Kotz, C. Wang, A. S. Levine, and C. J. Billington Urocortin in the hypothalamic PVN increases leptin and affects uncoupling proteins-1 and -3 in rats Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2002; 282(2): R546 - R551. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
