AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 280: R536-R546, 2001;
0363-6119/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (12)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Uno, T.
Right arrow Articles by Shibata, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Uno, T.
Right arrow Articles by Shibata, M.
Vol. 280, Issue 2, R536-R546, February 2001

Role of inferior olive and thoracic IML neurons in nonshivering thermogenesis in rats

Tadashi Uno and Masaaki Shibata

Department of Biometeorology, Yamanashi Institute of Environmental Sciences, Fuji-Yoshida, Yamanashi 403 - 0005, Japan

Removal of the midbrain tonic inhibitory mechanism on nonshivering thermogenesis (NST) results in increased temperatures of the interscapular brown adipose tissue (IBAT) and rectum (TIBAT and Trec, respectively) via an enhanced central sympathetic output. Because it is unlikely that neurons (primary) of the midbrain inhibitory mechanism tonically inhibit the IBAT monosynaptically, there must be secondary or tertiary neurons posterior to the midbrain. Such neurons, therefore, may increase their activity during enhanced NST after removal of the midbrain tonic inhibition. The aim of the present experiments was to localize these secondary or tertiary neurons and establish descending neuronal pathway(s) that may project to the major NST effector IBAT. TIBAT and Trec increases induced by removal of the tonic inhibition by midbrain procaine microinjections were accompanied with appearance of c-Fos-positive neurons in the inferior olive (IO) and the intermediolateral (IML) cell column of the thoracic spinal cord. Electrical stimulation of and L-glutamate microinjections into the IO increased TIBAT and Trec. Midbrain procaine-induced TIBAT and Trec increases were blocked by electrolytic IO lesions. These results suggest that central thermal signals produced from the lower midbrain are transmitted to IBAT through the IO and IML and that the IO has a role in the central sympathetic functions.

tonic inhibition; body temperature regulation; brown adipose tissue; sympathetic nerve


This article has been cited by other articles:


Home page
 J. Physiol.Home page
M. C. Almeida, A. A. Steiner, N. C. Coimbra, and L. G. S. Branco
Thermoeffector neuronal pathways in fever: a study in rats showing a new role of the locus coeruleus
J. Physiol., July 1, 2004; 558(1): 283 - 294.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
S. F. Morrison
Central Pathways Controlling Brown Adipose Tissue Thermogenesis
Physiology, April 1, 2004; 19(2): 67 - 74.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
B. CANNON and J. NEDERGAARD
Brown Adipose Tissue: Function and Physiological Significance
Physiol Rev, January 1, 2004; 84(1): 277 - 359.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
G. F. DiBona
Thermoregulation
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2003; 284(2): R277 - R279.
[Full Text] [PDF]

Home page
 J. Neurosci.Home page
K. Nakamura, K. Matsumura, T. Kaneko, S. Kobayashi, H. Katoh, and M. Negishi
The Rostral Raphe Pallidus Nucleus Mediates Pyrogenic Transmission from the Preoptic Area
J. Neurosci., June 1, 2002; 22(11): 4600 - 4610.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online