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Veterans Affairs Medical Center, Omaha 68105; Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska 68178; and Arvid Wretlind Laboratory for Metabolic Research, Department of Surgery, Karolinska Institutet at Huddinge University Hospital, S-14186 Stockholm, Sweden
CCK is a physiological inhibitor of
gastric emptying and food intake. The pancreatic peptide amylin exerts
similar actions, yet its physiological importance is uncertain.
Objectives were to compare the dose-dependent effects of intravenous
infusion of amylin and CCK-8 on gastric emptying and food intake in
rats, and to assess whether physiological doses of amylin are
effective. Amylin and CCK-8 inhibited gastric emptying with mean
effective doses (ED50s) of 3 and 35 pmol · kg
1 · min1 and
maximal inhibitions of 60 and 65%, respectively. Amylin and CCK-8
inhibited food intake with ED50s of 8 and 14 pmol · kg1 · min1 and
maximal inhibitions of 78 and 69%, respectively. The minimal effective
amylin dose for each effect was 1 pmol · kg1 · min1. Our
previous work suggests that this dose increases plasma amylin by an
amount comparable to that produced by a meal. These results support the
hypothesis that amylin acts as a hormonal signal to the brain to
inhibit gastric emptying and food intake and that amylin produces
satiety in part through inhibition of gastric emptying.
meal patterns; satiety; stomach; intravenous; potency; efficacy
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