AJP - Regu Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 280: R831-R842, 2001;
0363-6119/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (11)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Stricker, E. M.
Right arrow Articles by Smith, J. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Stricker, E. M.
Right arrow Articles by Smith, J. C.
Vol. 280, Issue 3, R831-R842, March 2001

Osmoregulation in water-deprived rats drinking hypertonic saline: effect of area postrema lesions

Edward M. Stricker1, Carl F. Craver1, Kathleen S. Curtis1, Kimberly A. Peacock-Kinzig2, Alan F. Sved1, and James C. Smith2

1 Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260; and 2 Department of Psychology, Florida State University, Tallahassee, Florida 32306

Rats drank rapidly when 0.3 M NaCl was the only drinking fluid available after overnight water deprivation, consuming ~200 ml/24 h. Although such large intakes of this hypertonic solution initially elevated plasma osmolality, excretion of comparable volumes of urine more concentrated than 300 meq Na+/l ultimately appears to restore plasma osmolality to normal levels. Rats drank ~100 ml of 0.5 M NaCl after overnight water deprivation, but urine Na+ concentration (UNa) did not increase sufficiently to achieve osmoregulation. When an injected salt load exacerbated the initial dehydration caused by water deprivation, rats increased UNa to void the injected load and did not significantly alter 24-h intake of 0.3 or 0.5 M NaCl. Rats with lesions of area postrema had much higher saline intakes and lower UNa than did intact control rats; nonetheless, they appeared to osmoregulate well while drinking 0.3 M NaCl but not while drinking 0.5 M NaCl. Detailed analyses of drinking behavior by intact rats suggest that individual bouts were terminated by some rapid postabsorptive consequence of the ingested NaCl load that inhibited further NaCl intake, not by a fixed intake volume or number of licks that temporarily satiated thirst.

oxytocin; thirst; vasopressin


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. Godino, L. A. De Luca Jr., J. Antunes-Rodrigues, and L. Vivas
Oxytocinergic and serotonergic systems involvement in sodium intake regulation: satiety or hypertonicity markers?
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1027 - R1036.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. L. Hoffmann, M. DenBleyker, J. C. Smith, and E. M. Stricker
Inhibition of thirst when dehydrated rats drink water or saline
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2006; 290(5): R1199 - R1207.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. E. Lohmeier
Neurohypophysial hormones
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2003; 285(4): R715 - R717.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
O. Skott
Body sodium and volume homeostasis
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2003; 285(1): R14 - R18.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
E. M. Stricker, J. B. Callahan, W. Huang, and A. F. Sved
Early osmoregulatory stimulation of neurohypophyseal hormone secretion and thirst after gastric NaCl loads
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2002; 282(6): R1710 - R1717.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online