AJP - Regu AJP: Advances in Physiology Education
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 280: R929-R934, 2001;
0363-6119/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (50)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hansen, M. K.
Right arrow Articles by Maier, S. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hansen, M. K.
Right arrow Articles by Maier, S. F.
Vol. 280, Issue 4, R929-R934, April 2001

The contribution of the vagus nerve in interleukin-1beta -induced fever is dependent on dose

Michael K. Hansen1, Kevin A. O'Connor1, Lisa E. Goehler1,2, Linda R. Watkins1, and Steven F. Maier1

1 Department of Psychology and Center for Neuroscience, University of Colorado at Boulder, Boulder, Colorado 80309; and 2 Department of Psychology, University of Virginia, Charlottesville, Virginia 22904

It has been suggested that proinflammatory cytokines communicate to the brain via a neural pathway involving activation of vagal afferents by interleukin-1beta (IL-1beta ), in addition to blood-borne routes. In support, subdiaphragmatic vagotomy blocks IL-1beta -induced, brain-mediated responses such as fever. However, vagotomy has also been reported to be ineffective. Neural signaling would be expected to be especially important at low doses of cytokine, when local actions could occur, but only very small quantities of cytokine would become systemic. Here, we examined core body temperature after intraperitoneal injections of three doses of recombinat human IL-1beta (rh-IL-1beta ). Subdiaphragmatic vagotomy completely blocked the fever produced by 0.1 µg/kg, only partially blocked the fever produced by 0.5 µg/kg, and had no effect at all on the fever that followed 1.0 µg/kg rh-IL-1beta . Blood levels of rh-IL-1beta did not become greater than normal basal levels of endogenous rat IL-beta until the 0.5-µg/kg dose nor was IL-1beta induced in the pituitary until this dose. These results suggest that low doses of intraperitoneal IL-1beta induce fever via a vagal route and that dose may account for some of the discrepancies in the literature.

cytokines; vagotomy; immune-to-brain communication; rat


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. B. Buchanan, E. Peloso, and E. Satinoff
A warmer ambient temperature increases the passage of interleukin-1{beta} into the brains of old rats
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2008; 295(1): R361 - R368.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
Y. Ootsuka, W. W. Blessing, A. A. Steiner, and A. A. Romanovsky
Fever response to intravenous prostaglandin E2 is mediated by the brain but does not require afferent vagal signaling
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2008; 294(4): R1294 - R1303.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. Ching, H. Zhang, N. Belevych, L. He, W. Lai, X.-a. Pu, L. B. Jaeger, Q. Chen, and N. Quan
Endothelial-Specific Knockdown of Interleukin-1 (IL-1) Type 1 Receptor Differentially Alters CNS Responses to IL-1 Depending on Its Route of Administration
J. Neurosci., September 26, 2007; 27(39): 10476 - 10486.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
L. Elander, L. Engstrom, M. Hallbeck, and A. Blomqvist
IL-1beta and LPS induce anorexia by distinct mechanisms differentially dependent on microsomal prostaglandin E synthase-1
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R258 - R267.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
B. Kis, T. Isse, J. A. Snipes, L. Chen, H. Yamashita, Y. Ueta, and D. W. Busija
Effects of LPS stimulation on the expression of prostaglandin carriers in the cells of the blood-brain and blood-cerebrospinal fluid barriers
J Appl Physiol, April 1, 2006; 100(4): 1392 - 1399.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L. Chen, D. Duricka, S. Nelson, S. Mukherjee, S. G. Bohnet, P. Taishi, J. A. Majde, and J. M. Krueger
Influenza virus-induced sleep responses in mice with targeted disruptions in neuronal or inducible nitric oxide synthases
J Appl Physiol, July 1, 2004; 97(1): 17 - 28.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
F. J.-P. Miao, P. G. Green, and J. D. Levine
Mechanosensitive duodenal afferents contribute to vagal modulation of inflammation in the rat
J. Physiol., January 1, 2004; 554(1): 227 - 235.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. Campisi,, M. K. Hansen,, K. A. O'Connor,, J. C. Biedenkapp,, L. R. Watkins,, S. F. Maier,, and M. Fleshner
Circulating cytokines and endotoxin are not necessary for the activation of the sickness or corticosterone response produced by peripheral E. coli challenge
J Appl Physiol, November 1, 2003; 95(5): 1873 - 1882.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
H. Scholz
Fever
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2003; 284(4): R913 - R915.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. Gatti, J. Beck, G. Fantuzzi, T. Bartfai, and C. A. Dinarello
Effect of interleukin-18 on mouse core body temperature
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2002; 282(3): R702 - R709.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. Hosoi, Y. Okuma, A. Ono, and Y. Nomura
Subdiaphragmatic vagotomy fails to inhibit intravenous leptin-induced IL-1beta expression in the hypothalamus
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2002; 282(2): R627 - R631.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online