| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Cardiovascular Medicine, Cardiovascular Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
Nitric oxide (NO) in the
nucleus tractus solitarii (NTS) plays an important role in regulating
sympathetic nerve activity. The aims of this study were to determine
whether the activation of N-methyl-D-aspartate
(NMDA) receptors in the NTS facilitates the release of
L-glutamate (Glu) via NO production, and, if so, to
determine whether this mechanism is involved in the depressor and
bradycardic responses evoked by NMDA. We measured the production of NO
in the NTS as NO
-nitro-L-arginine methyl ester
(L-NAME) on the changes in these levels. NMDA elicited
depressor and bradycardic responses and increased the levels of
NOx and Glu. L-NAME abolished the increases in
the levels of NOx and Glu and attenuated cardiovascular
responses evoked by NMDA. These results suggest that NMDA receptor
activation in the NTS induces Glu release through NO synthesis and that
Glu released via NO enhances depressor and bradycardic responses.
nitric oxide synthase; central nervous system; blood pressure; amino acid; microdialysis; nucleus tractus solitarii; N-methyl-D-aspartate
This article has been cited by other articles:
|
|
 |
|
  A. C. Kleiber, H. Zheng, H. D. Schultz, J. D. Peuler, and K. P. Patel Exercise training normalizes enhanced glutamate-mediated sympathetic activation from the PVN in heart failure Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2008; 294(6): R1863 - R1872. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Nozoe, Y. Hirooka, Y. Koga, Y. Sagara, T. Kishi, J. F. Engelhardt, and K. Sunagawa Inhibition of Rac1-Derived Reactive Oxygen Species in Nucleus Tractus Solitarius Decreases Blood Pressure and Heart Rate in Stroke-Prone Spontaneously Hypertensive Rats Hypertension, July 1, 2007; 50(1): 62 - 68. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Wang, Julian. F. R. Paton, and S. Kasparov Autonomic Neuroscience: Differential sensitivity of excitatory and inhibitory synaptic transmission to modulation by nitric oxide in rat nucleus tractus solitarii Exp Physiol, March 1, 2007; 92(2): 371 - 382. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Zhao, H. Chen, and B. M. Sharp Nicotine-Induced Norepinephrine Release in Hypothalamic Paraventricular Nucleus and Amygdala Is Mediated by N-Methyl-D-aspartate Receptors and Nitric Oxide in the Nucleus Tractus Solitarius J. Pharmacol. Exp. Ther., February 1, 2007; 320(2): 837 - 844. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kamendi, O. Dergacheva, X. Wang, Z.-G. Huang, E. Bouairi, C. Gorini, and D. Mendelowitz NO Differentially Regulates Neurotransmission to Premotor Cardiac Vagal Neurons in the Nucleus Ambiguus Hypertension, December 1, 2006; 48(6): 1137 - 1142. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. T. Talman NO and Central Cardiovascular Control: A Simple Molecule With a Complex Story Hypertension, October 1, 2006; 48(4): 552 - 554. [Full Text] [PDF]
|
|
|
|
|
|
H. Waki, D. Murphy, S. T. Yao, S. Kasparov, and J. F.R. Paton Endothelial NO Synthase Activity in Nucleus Tractus Solitarii Contributes to Hypertension in Spontaneously Hypertensive Rats Hypertension, October 1, 2006; 48(4): 644 - 650. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Wang, A. G. Teschemacher, J. F. R. Paton, and S. Kasparov Mechanism of nitric oxide action on inhibitory GABAergic signaling within the nucleus tractus solitarii FASEB J, July 1, 2006; 20(9): 1537 - 1539. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. R. Dias and E. Colombari Central nitric oxide modulates hindquarter vasodilation elicited by AMPA receptor stimulation in the NTS of conscious rats Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2006; 290(5): R1330 - R1336. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. C. R. Dias, M. Vitela, E. Colombari, and S. W. Mifflin Nitric oxide modulation of glutamatergic, baroreflex, and cardiopulmonary transmission in the nucleus of the solitary tract Am J Physiol Heart Circ Physiol, January 1, 2005; 288(1): H256 - H262. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Chianca Jr., L.-H. Lin, D. N. Dragon, and W. T. Talman NMDA receptors in nucleus tractus solitarii are linked to soluble guanylate cyclase Am J Physiol Heart Circ Physiol, April 1, 2004; 286(4): H1521 - H1527. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. R. Dias, E. Colombari, and S. W. Mifflin Effect of nitric oxide on excitatory amino acid-evoked discharge of neurons in NTS Am J Physiol Heart Circ Physiol, January 1, 2003; 284(1): H234 - H240. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. M. Stauss Baroreceptor reflex function Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2002; 283(2): R284 - R286. [Full Text] [PDF]
|
|
|
|
 |
|
 K. P. Patel, Y.-F. Li, and Y. Hirooka Role of Nitric Oxide in Central Sympathetic Outflow Experimental Biology and Medicine, October 1, 2001; 226(9): 814 - 824. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
